Bioinorganic Chemistry

Paper Code: 
CHY 424 A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

To learn the importance of metalloenzymes used in biosystems and metals in medicine. 

14.00
Unit I: 
Metal Ions in Living System

Introduction: Essential and trace elements, principles of coordination chemistry in biological systems, HSAB concept, chelate effect, Irving Williams series, pKa values of coordination ligands, tuning of redox potential, biopolymer effects, ligand exchange rates, substitution raeactions, electrone transfer reactions.

Molecular mechanism – ion transport across membranes, active transport of Na-K (ion pumps). Chlorophyll and their role in photosynthesis, (Calcium cycle and quantum efficiency) PS I and PS II system.

Calcium in Biological Systems: calcium in living cells, transport and regulation of Ca2+ ions in higher organisms, molecular aspects of intramolecular processes, extracellular binding proteins.

 

13.00
Unit II: 
Iron in Biological Systems

Metal Storage and Transport: Structure and function of Ferritin, Transferrin, Siderophores, haemoglobin, myoglobin, haemocyanin and haemerythrin.

Electron transport proteins: Structure and function of cytochromes with special reference to cytochrome c, iron sulphur proteins- ferredoxins. biological nitrogen fixation and its mechanism, nitrogenenases, dinitrogen complexes as models for nitrogen fixation. dioxygen model complexes of Fe, Co and Cu.

13.00
Unit III: 
Metalloenzymes

Zinc enzymes: carboxypeptidase and carbonic anhydrase, alcoholic dehydrogenase. iron enzymes: catalase, peroxidase and cytochrome P-450. copper enzymes: superoxide dismutase, xanthine oxidase, vitamin B12 and B12 coenzymes.

 

8.00
Unit IV: 
Metals in Medicine

Fe, Zn and Cu deficiency, toxicity: Cu overload and wilson’s disease, iron toxicity, toxicity of As, Cd, Hg and Pb. Metal complexes in medicines, chelation therapy, BAL, penicilamine, poly amino carboxylic acid and desferrioxamine-gold compounds, rheumatoid arthritis, pt complexes as anticancer drug, metal complexes in radiodiagnosis, MRI.

 

12.00
Unit V: 
Metal-nucleic Acid Interactions

Basics- nucleic acid structure, fundamental interactions and reactions with nucleic acids, applications of different metal complexes that binds nucleic acids, conformational probes, metal-nucleic acid interactions with special references to zinc finger protein.

Essential Readings: 
  1. Principles of Bioinorganic Chemistry; First Edition; S. J. Lippard, J.M. Berg; Panima Publishing Corporation, New Delhi, 1995.
  2. Bioinorganic Chemistry; First, South Asian Edition; I. Bertini, H. B. Gray, S. J. Lippard; Viva Books Pvt Ltd., New Delhi, 1998.
  3. Bioinorganic Chemistry; First Edition; M. Satake, Y. Mido; Discovery Publishing House, New Delhi, 2003.
  4. Principles of Biochemistry; Third Edition; A. L. Lehninger, McMillan Press, London, 2002.

 

Academic Year: