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Bioinorganic Chemistry
Course Objectives :
The course aims to make students understand the role of various elements in the living system, to acquire basic knowledge about the structure and functions of metalloenzymes and to know about the mechanism of binding interactions of metal complexes with biomolecules and metal based drug action.
Course Outcomes (Cos):
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CHY 424(A) |
Bioinorganic Chemistry |
The students will be able to-
CO134-apply the principles of coordination chemistry in biological systems. CO135-explain the structures and functions of variety of metalloenzymes CO136-comprehend the importance of metals in medicine. CO137-discuss the various fundamental interactions of nucleic acids with metal ions. |
Class Lecture
Tutorials
Quiz
Problem solving
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Group Discussion
Quiz
Assignment
PowerPoint Presentation
Semester End Exam
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Introduction: Essential and trace elements, principles of coordination chemistry in biological systems, HSAB concept, chelate effect, Irving Williams series, pKa values of coordination ligands, tuning of redox potential, biopolymer effects, ligand exchange rates, substitution reactions, electron transfer reactions.
Molecular mechanism – ion transport across membranes, active transport of Na-K (ion pumps). Chlorophyll and their role in photosynthesis, (Calcium cycle and quantum efficiency) PS I and PS II system.
Calcium in Biological Systems: calcium in living cells, transport and regulation of Ca2+ ions in higher organisms, molecular aspects of intramolecular processes, extracellular binding proteins.
Metal Storage and Transport: Structure and function of Ferritin, Transferrin, Siderophores, hemoglobin, myoglobin, hemocyanin and hemerythrin.
Electron transport proteins: Structure and function of cytochromes with special reference to cytochrome c, Iron-Sulphur proteins- Ferredoxins. biological nitrogen fixation and its mechanism, nitrogenenases, dinitrogen complexes as models for nitrogen fixation. Dioxygen model complexes of Fe, Co and Cu.
Zinc enzymes: carboxypeptidase and carbonic anhydrase, alcoholic dehydrogenase.
iron enzymes: Catalase, peroxidase and cytochrome P-450.copper enzymes: Superoxide dismutase, xanthine oxidase, vitamin B12 and B12 coenzymes.
Fe, Zn and Cu deficiency, toxicity: Cu overload and wilson’s disease, iron toxicity, toxicity of As, Cd, Hg and Pb. Metal complexes in medicines, chelation therapy, BAL, penicilamine, poly amino carboxylic acid and desferrioxamine-gold compounds, rheumatoid arthritis, Pt complexes as anticancer drug, metal complexes in radiodiagnosis, MRI.
Basics- nucleic acid structure, fundamental interactions and reactions with nucleic acids, applications of different metal complexes that binds nucleic acids, conformational probes, metal-nucleic acid interactions with special references to zinc finger protein.
- Principles of Bioinorganic Chemistry; First Edition; S. J. Lippard, J.M. Berg; Panima Publishing Corporation, New Delhi, 2005.
- Bioinorganic Chemistry; First South Asian Edition; I.Bertini, H.B.Gray, S.J.Lippard; Viva Books Pvt Ltd., New Delhi, 2008.
- Bioinorganic Chemistry; First Edition; M.Satake, Y.Mido; Discovery Publishing House, New Delhi, 2011.
- Lehninger Principles of Biochemistry; Seventh Edition; David L. Nelson, Michael M. Cox; W H Freeman,2017.
