Biology for Chemists

Paper Code: 
24CHY125 (B)
Credits: 
2
Contact Hours: 
30.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to-

understand the basic processes which link the biological systems with the chemical systems and to provide them with the basic knowledge and insight about the three-dimensional (3D) structure of macromolecules (protein and nucleic acids) and the relationship between their structure and function.

 

Course Outcomes (COs):

Course

Learning outcome

(at course level)

Learning and Teaching Strategies

Assessment Strategies

Course Code

Course

Title

 

24CHY125 (B)

 

Biology for Chemists (Theory)

CO31: Differentiate between prokaryotic and eukaryotic cells and describe the structure and functions of important cell organelles and discuss Krebs cycle and oxidative phosphorylation.

CO32: Illustrate the structure and function of amino acids and proteins. Assess the effects of different denaturing agents on protein structure and functions and elaborate the theories of enzyme kinetics, mechanisms of enzyme catalysis and their regulation in the cell.

CO33: Explain classification, structure and functions of different types of carbohydrates and differentiate between simple and complex carbohydrates.

CO34: Discuss Structure, nomenclature and functions of lipids, and differentiate between saturated and unsaturated fatty acids. Elaborate the process of α & β-oxidation.

CO35: Classify purines and pyrimidines, discuss the structure, types and different models of DNA and RNA.

CO36: Contribute effectively in course-specific interaction.

Approach in teaching:

Interactive lectures, tutorials, group discussions and e-learning.

 

Learning activities for the students:

Peer learning, e- learning, problem solving through tutorials and group discussions.

 

 

Written examinations,

Assignments, Quiz

 

 

6.00
Unit I: 
Concept of Cell

Origin of life: Prokaryotes and eukaryotes, difference between plant and animal cell, hierarchy of molecular organization of living systems, a brief concept of cell organelles and their functions- nucleus, plasma membrane, chloroplast, Golgi bodies, endoplasmic reticulum, lysosomes, ribosomes and mitochondria, ATP synthesis, substrate level phosphorylation like glycolysis and Kreb’s cycle and oxidative level phosphorylation.

 

7.00
Unit II: 
Amino Acids & Proteins

Introduction, classification, optical isomerism, chemical properties, acid-base properties- peptide bond formation and properties, protein structure- primary, secondary, tertiary & quaternary structures, denaturation of proteins, Ramachandran plot, determination of primary structure - sequencing strategies, N-terminal and C-terminal sequencing, synthesis of amino acids by reductive amination, GS-GOGAT system and transamination.

Enzymes: Introduction, classification of enzymes, mechanism of enzyme action, enzyme kinetics, Michaelis – Menten equation and enzyme inhibition.

6.00
Unit III: 
Carbohydrates

Classification, structure and functions of monosaccharides, disaccharides, polysaccharides-starch, cellulose, glycogen, chitin and pectin, glycoconjugates, proteoglycans, glycoproteins and glycolipids.

5.00
Unit IV: 
Lipids

Structure, sources, nomenclature and functions of lipids, saturated and unsaturated fatty acids, classification- simple, compound and derived lipids (steroids and cholesterol), synthesis of long chain fatty acids, α-oxidation, β-oxidation.

 

6.00
Unit V: 
Nucleic Acids

Purines and Pyrimidines: Structures of purine and pyrimidine bases, nucleosides and nucleotides.

DNA, Double helical structure of DNA(Watson and Crick model) , types of DNA, A, B, C and Z forms, replication.

RNA, RNA structure and its types- rRNA, mRNA, and tRNA, ribozymes, differences between DNA & RNA.

Essential Readings: 
  1. Lehninger Principles of Biochemistry, International Edition, Seventh Edition; D. L. Nelson,          M. Cox; W.H. Freeman, 2017.
  2. Biochemistry, Fourth Edition; D. Voet; John Wiley and Sons, 2011.

 

References: 
  1. Biochemistry, Ninth Edition; L. Stryer; W.H. Freeman and Company, 2019
  2. Biochemistry, First Indian Reprint; J. D. Rawn; Tanima Publishing Corporation, New Delhi,   2004.
  3. Outline of Biochemistry, Fifth Edition; E.E. Conn and P.K. Stumpf; John Wiley and Sons           Inc., New Delhi, 2006.

 

e- Resources:

  1. https://egyankosh.ac.in/bitstream/123456789/16222/1/Unit-1.pdf
  2. https://egyankosh.ac.in/bitstream/123456789/71691/1/unit-1.pdf
  3. https://egyankosh.ac.in/bitstream/123456789/15773/1/Unit-2.pdf
  4. https://epgp.inflibnet.ac.in/epgpdata/uploads/epgp_content/S000002BI/P000983/M01688      2/ET/1491301143P05M05Lipids-TypesI.pdf
  5. https://epgp.inflibnet.ac.in/epgpdata/uploads/epgp_content/S000002BI/P000983/M01689      8/ET/1491302127P05M21Lipids-OxidationI.pdf

 

Academic Year: