Course Objective(s):
This course will enable the students to –
Course Outcomes (Cos):
Course Outcomes
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Teaching and learning strategies |
Assessment strategies |
On completion of this course, the students will be able to- CO162: explain the basic principles of different types of spectroscopy and their applications to elucidate the structure of simple organic molecules. CO163: identify and analyze different molecules based on selection rules and fundamental theory of spectroscopy CO164: differentiate between compounds of different electronic, structural and functional constitution in 13C-NMR using the basic theoretical knowledge of techniques like COSY and NOSEY CO165: interpret and distinguish between the structures of simple compounds using the Mass, IR and NMR spectral data. CO166: calculate the λmax for different organic compounds using Woodward-Feiser rules. |
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General principles- different regions of electromagnetic radiation, quantisation of energy, regions of the spectrum, introduction to absorption and emission spectroscopy.
UV Spectroscopy- types of electronic transitions, λmax, chromophores and auxochromes, bathochromic and hypsochromic shifts, intensity of absorption, application of Woodward Rules for calculation of λmax for the following systems- conjugated dienes (alicyclic, homoannular and heteroannular), α,β unsaturated carbonyls, carboxylic acids and esters.
Fundamental and non-fundamental molecular vibrations, fingerprint region and its significance, overtones, fermi resonance, Hooke’s Law, selection rules, IR absorption peaks of O, N and S containing functional groups, effect of H-bonding, conjugation, resonance and ring size on IR absorption, application of IR spectroscopy in detection of functional group in simple organic molecules.
Basic principles of proton magnetic resonance, chemical shift and factors influencing it, spin–spin coupling and coupling constant, anisotropic effects in alkene, alkyne, aldehydes and aromatic compounds, interpretation of NMR spectra of simple compounds.
13C NMR spectroscopy- general considerations, chemical shift, (aliphatic, olefinic, alkyne, aromatic, heteroaromatic & carbonyl carbon), proton (1H) coupled 13C NMR spectrum, off resonance, elementary idea of 2D NMR spectroscopy- COSY, NOESY NMR spectra.
Combined applications- structural determination of simple organic compounds using UV, IR, 1H & 13C NMR spectral data.
Introduction, instrumentation, generation of ions- EI, CI, FD and FAB methods, determination of molecular weight, molecular ion peak, base peak, nitrogen rule, isotope peak, metastable ions, fragmentation – basic fragmentation types and rules, factors influencing fragmentation, McLafferty rearrangement, fragmentation pattern of hydrocarbons, alcohols, ethers, ketones, aldehydes, carboxylic acids, amines, nitro compounds, alicyclic and heterocyclic compounds.
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