Course Objectives :
The course aims to describe the process of identification and isolation of natural products, their chemical synthesis, biological activities, ecological relevance and possible applications in the fields of pharmacology using selected examples. It also aims to introduce students with the fundamental concepts of drug discovery and development emphasizing specific classes of drugs.
Course Outcomes (COs):
COURSE |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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CHY- 424(B) |
Natural Products and Medicinal Chemistry |
The students will be able to-
CO156- recognize various types of natural products along with their applications in medicinal chemistry. CO157-explain the different techniques that are used in natural products chemistry as well as their structure elucidation. CO158-describe the key concepts and strategies used during drug discovery, development and mode of action. CO159-explain the importance of quantitative structure-activity relationship (QSAR) as a potential source for rational drug design in brief. |
Interactive Lectures
Discussion
Tutorials
Problem Solving
Power Point Presentation |
Quiz
Assignments
Written Test
Semester End Exam |
Classification, nomenclature, occurrence, general methods of structure determination, isoprene rule; Structure determination, stereochemistry and synthesis of the following representative molecules: Citral, Geraniol, Menthol and β-Carotene.
Definition, nomenclature, physiological action, occurrence, general methods of structure elucidation, degradation, classification based on nitrogen heterocyclic ring. Structure, stereochemistry and synthesis of the following: Ephedrine, (+)-Nicotine and Morphine.
Occurrence, nomenclature, basic skeleton, Diel’s hydrocarbon and stereochemistry. Structure determination and synthesis of Cholesterol, Androsterone, Testosterone, Estrone.
Introduction to drugs, discovery, development and delivery. Agonists and antagonists. Relation of Drug structure and its chemical and biological properties. Structure-activity and quantitative relationship. Drug targets.
General introduction and mode of action of- antiviral, antibiotics and anti-AIDS drugs. Anti-inflammatory, analgesics, antihistamines, anti-hypertensive and anti-cancer drugs. General study of hormones, classification based on solubility and structures, mode of action of water soluble and fat-soluble messengers.