Coming soon
Natural Products and Medicinal Chemistry
This course will enable the students to
describe the process of identification and isolation of natural products, their chemical synthesis, biological activities, ecological relevance and possible applications in the fields of pharmacology using selected examples. It also aims to introduce students with the fundamental concepts of drug discovery and development emphasizing specific classes of drugs.
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Course |
Learning outcome (at course level) |
Learning and Teaching Strategies |
Assessment Strategies |
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Course Code |
Course Title |
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24CHY424 B |
Natural Products and Medicinal Chemistry (Theory) |
CO167: Discuss the structure, properties and stereochemistry of prescribed terpenoids & carotenoids. CO168: Explain different techniques used for the structure elucidation of alkaloids along with the structure and physiological actions of the stipulated alkaloids. CO169: Deduce the structure of complex natural products like steroids and appraise their biological properties. CO170: Describe the key concepts and strategies used during drug discovery, development and mode of action. CO171:Explain the importance of quantitative structure-activity relationship (QSAR) as a potential source for rational drug design in brief. CO172:Contribute effectively in course-specific interaction. |
Approach in teaching: Interactive lectures, tutorials, group discussions and e-learning.
Learning activities for the students: Peer learning, e- learning, problem solving through tutorials and group discussions.
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Written examinations, Assignments, Quiz
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Classification, nomenclature, occurrence, general methods of structure determination, isoprene rule; Structure determination, stereochemistry and synthesis of the following representative molecules- citral, geraniol, menthol and β-Carotene.
Definition, nomenclature, physiological action, occurrence, general methods of structure elucidation, degradation, classification based on nitrogen heterocyclic ring. Structure, stereochemistry and synthesis of the following: Ephedrine, (+)-Nicotine and Morphine.
Occurrence, nomenclature, basic skeleton, Diels- hydrocarbon and stereochemistry. Structure
determination and synthesis of cholesterol, androsterone, testosterone, estrone.
Introduction to drugs, discovery, development and delivery, agonists and antagonists, relation of drug structure and its chemical and biological properties.
Structure-activity and quantitative relationship. Drug targets.
General introduction and mode of action of- antiviral, antibiotics and anti-AIDS drugs, anti-inflammatory, analgesics, antihistamines, anti-hypertensive and anti-cancer drugs.
General study of hormones, classification based on solubility and structures, mode of action of water soluble and fat-soluble messengers.
- Organic Chemistry, Vol II; Sixth Edition; I.L. Finar; Pearson Education, New Delhi, 2013.
- Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, Twelfth Edition, Wolters Kluwer India Pvt. Ltd., 2010.
- Burgers’s Medicinal Chemistry and Drug Discovery, Sixth Edition, D.J. Abraham, Wiley- Blackwell, 2003.
- Introduction to Medicinal Chemistry, First Edition; A Gringauz, Wiley-VCH, 1996.
- Organic Chemistry, Sixth Edition; R. T. Morrison, R. N. Boyd; Pearson Education India, New Delhi, 2017.
- An Introduction to Drug Design, Second Edition, S. N. Pandeya and J.R. Dimmock, New Age International, 2019.
- Goodmann and Gilman’s Pharmacological Basis of Therapeutics, Thirteenth Edition, Laurence L. Brunton, Mc-Graw Hill, 2017.
- The Organic Chemistry of Drug Design and Drug Action, Third Edition, R. B. Silverman, Academic Press, 2014.
- Strategies for Organic Drug Synthesis and Design, Second Edition; D. Lednicer, Wiley-Blackwell, 2008.
e-Resources:
- http://oms.bdu.ac.in/ec/admin/contents/1_16SCCCH8_2020051904202312.pdf (Natural Products)
- http://www.pharmacy180.com/group/medicinal-chemistry-6/ (Medicinal Chemistry)
