Course Objectives:
This course will enable the students to –
enrich the ability to compare the effect of heteroatoms on structure and reactivity of simple and benzofuzed aromatic compounds and to touch up on the exclusive chemistry of nitrogen containing functional groups.
gain perspective on different classes of chemotherapeutic agents.
Course Outcomes (COs):
Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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CHY 602 |
Nitrogen Containing Organic Compounds and Some Aspects of- Medicinal Chemistry
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The students will be able to –
CO101: describe the structural and chemical properties of five and six membered aromatic heterocycles CO102: outline the preparations and reaction mechanisms of benzofuzed heterocycles CO103: discuss the formation and reactivity of aliphatic as well as aromatic nitro compounds CO104: differentiate between 1°/2°/3° amines and discuss their role in acting as a base, phase transfer catalyst and as a precursor to diazotization CO105: classify chemotherapeutic agents on the basis of their medicinal applications and define their structure, function and synthesis. |
Interactive Lectures
Discussions
Tutorials
Quiz
Problem solving
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Continuous Assessment (Written test)
Quiz
Closed-book and open-book tests
Assignment
Group Activity
Semester End Exam |
Nomenclature of five and six membered heterocycles; molecular orbital picture and aromatic character of pyrrole, pyridine, furan and thiophene; methods of synthesis, chemical reactions with respect to electrophilic substitution reactions, nucleophilic substitution reactions in pyridine and pyrrole (mechanism and orientation), comparison of basicity of pyridine, piperidine and pyrrole.
Preparation and reactions of indole, quinoline and isoquinoline with special reference to Fischer indole synthesis, Skraup synthesis and Bischler – Napieralski synthesis.
Pre requisite: Aliphatic nitro compounds.
Preparation, reactions – electrophilic and nucleophilic substitution, effect of the substituents on the acidity of phenols, effect of nitro group on nucleophilic substitution of aryl halides, reduction.
Classification and distinction between primary, secondary and tertiary amines; relative basic strength of aliphatic and aromatic amines; diazotization- mechanism, stability of diazonium salts,
Self Study: diazo coupling
Introduction, lock and key theory.
Synthesis and medicinal applications of -Sulpha drugs: Sulphadiazine (sulpha pyrimidine), sulpha guanidine, sulphamethazine, sulpha pyridine.
Analgesics: Aspirin, phenacetin, paracetamol.
Antimalarials: Chloroquine, pamaquine.
Antibiotics: Penicillin, streptomycin and chloramphenicol.