Coming soon
Organic Chemistry Lab II
This course will enable the students to
acquire knowledge of synthesis by conventional and non-conventional methods, handling of hazardous chemicals and to enhance learning of physical and spectroscopic techniques.
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Course |
Learning outcome (at course level) |
Learning and Teaching Strategies |
Assessment Strategies |
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Course Code |
Course Title |
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24CHY327 |
Organic Chemistry Lab II (Practical) |
CO128: Characterize organic molecules by different spectral techniques. CO129: Demonstrate and apply common laboratory techniques for organic synthesis. CO130:Employ spectrophotometric techniques for the estimations of prescribed biomolecules. CO131:Contribute effectively in course-specific interaction. |
Approach in teaching: Laboratory instructions and Demonstrations.
Learning activities for the students: Peer learning, hands-on-learning, interpretation of data, record writing and learning through virtual labs
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Green Chemistry (10 Hours)
Green Chemistry & sustainability, twelve principles of green chemistry, atom economy, E-factor, green chemistry tools.
Solvents:Types based on hazards, applications, green solvents-supercritical fluids, ionic liquids, water, solvent free solid phase reaction.
Alternative energy sources, ultrasound, microwave, reactions at high pressure in constrained media, renewable sources, C1 chemistry.
Green catalysts-types, advantages and disadvantages, applications in organic synthesis.
Synthesis (Green Methods / Conventional Methods) (30 Hours)
- One step synthesis
- Aldol condensation (Synthesis of dibenzal propanone)
- Acetylation (synthesis of acetanilide from aniline)
- Pechmann Condensation for Coumarin synthesis (Clay catalyzed solid state synthesis of 7- hydroxy -4-methyl coumarin)
- Bromination of phenol
- Two step synthesis (any three)
- Benzoin → benzil → benzilic acid
- Benzophenone → benzopinacol → benzopinacolone
- Acetanilide → p-bromoacetanilide → p-bromoaniline
- Acetanilide → p-nitroacetanilide → p-nitroaniline
- Resorcinol → fluorescein → eosin
- Phthalic anhydride → phthalimide → anthranilic acid
Extraction of Organic Compounds from Natural Resources (any three) (20 Hours)
- Isolation of caffeine from tea leaves.
- Isolation of casein from milk.
- Isolation of lactose from milk.
- Isolation of nicotine dipicrate from tobacco.
Spectroscopy (10 Hours)
Identification of organic compounds (with emphasis on isomeric studies and calculation of % ratio of tautomers) by the spectral analysis.
Spectrophotometric Estimations (any three) (20 Hours)
- Protein
- Carbohydrate
- Cholesterol
- Phosphate
- Ascorbic acid
Scheme of Examination
The duration of examination will be 6 hrs.
The following exercises will be set in the examination
Organic Synthesis 26 marks
Spectral Problems 14 marks
Spectrophotometric Estimation 15 marks
Viva 15 marks
Total 70 marks
1.Organic synthesis
This exercise carries 26 marks. Either 2 one step synthesis or two step synthesis will be allotted to the candidates by lot. The yield, purity, crystallization and recording of m.p. will be given due consideration while awarding marks.
2.Spectral Problems
This exercise carries 14 marks. The students may be provided with either spectral problems or data base problems.
3.Spectrophotometric Estimation
This exercise carries 15 marks. Three marks are reserved for the preparatory work, setting up of an instrument and experimental skills. The distribution of remaining 12 marks are as follows.
Correct observation and proper recording 4 marks
Standard curve 4 marks
Result 4marks
4.Viva
Oral questions shall generally be asked over the work assigned to the candidate. The purpose is to find out as to what extent the candidate has understanding the basic principles of chemistry.
- Vogel’s Textbook of Practical Organic Chemistry, Fifth Edition, B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell; Addison – Wesley Publishing Company, 2014.
- Practical Organic Chemistry, Fourth Edition; F.C. Mann and B.C. Saunders; Pearson Education, New Delhi, 2013.
- Advanced Practical Organic Chemistry, J. Leonard, B. Lygo and G. Procter; Third Edition; CRC Press, 2013.
- Green Chemistry: Introductory Text, Third Edition; M. Lancaster; Royal Society of Chemistry (London), 2016.
e-Resources:
- https://chem.libretexts.org/Bookshelves/Ancillary_Materials/Laboratory_Experiments/Wet_Lab_Experiments/Organic_Chemistry_Labs/Experiments/3%3A_Extraction_of_Caffeine_(Experiment) (Isolation of caffeine from tea leaves)
- https://youtu.be/sPhJWBL17OQ (Isolation of caffeine from tea leaves)
- https://vlab.amrita.edu/?sub=3&brch=63&sim=158&cnt=1 (Isolation of casein from milk-
- https://studylib.net/doc/5885894/experiment-5--isolation-of-casein-and-lactose-from-milk (Isolation of lactose from milk)
- https://youtu.be/DBS5g4BoSZY (Isolation of lactose from milk) https://youtu.be/16lGxX19x9M (Isolation of nicotine dipicrate from tobacco)
- http://www.ijcrt.org/papers/IJCRT2008374.pdf (Isolation of nicotine dipicrate from tobacco)
