ORGANOMETALLICS, BIOINORGANIC CHEMISTRY, POLYNUCLEAR HYDROCARBONS AND UV, IR SPECTROSCOPY

Paper Code: 
D-CHY 501 A
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Objective(s):
This course will enable the students to -

  • understand about the basics of organometallic chemistry, structure and nature of bonding in metal carbonyls
  • gain an in-depth knowledge about vitality of different types of metal ions in biosystems
  • enrich the ability to compare the effect of heteroatoms on structure and reactivity of simple and polynuclear aromatic compounds and to touch up on the exclusive chemistry of nitrogen containing functional groups.
  • apply the key concepts of IR and UV spectroscopy in the structure elucidation of various known and unknown organic molecules.

Course Outcomes (COs):

Course Outcomes

Teaching Learning Strategies

Assessment

Strategies

On completion of this course, the students will be able to-

 

CO36:  discuss the classification, nomenclature, preparation, properties, bonding, structure and applications of simple organometallic compounds and metallic carbonyls.

CO37: differentiate between bulk and trace elements, explain the importance of metal ions in biological systems and describe the structure and functions of different metalloenzymes.

CO38: describe the structural and chemical properties of five and six membered aromatic heterocycles and active methylene groups

CO39: calculate the λmax for different organic compounds using Woodward-Fieser rule.

CO40: relate the theoretical knowledge & selection rules of IR to the spectral analysis of simple compounds.
  • Interactive lectures
  • Tutorials
  • Group discussions
  • Use of models
  • Digital learning
  • Problem solving sessions
  • Assertion and Reasoning

     
  • Oral and written examinations
  • Assignments
  • Quiz

 

 

 

 

 

18.00
Unit I: 
Chemistry of transition metals and Organometallic Compounds

Transition Metals: Preparation and important properties of the following compounds-Peroxo compounds of Cr, K2Cr2O7, KMnO4, K4[Fe(CN)6], sodium nitroprusside, [Co(NH3)6]Cl3, Na3[Co(NO2)6].

Organometallic Compounds: Definition, nomenclature and classification of organometallic compounds; Hapticity(η) of organometallic ligands, 18-electron rule. Preparation, properties and structure of alkyls and aryls of Li.

Structure and bonding in metal ethylenic complex–Zeise’s salt (η2) and metal cyclopentadienyl complex- Ferrocene(η5).

Introduction to π acceptor ligands, definition, classification, general methods of preparation, properties, structure and nature of bonding (Synergic effect: VB approach and MO approach) in mononuclear carbonyls.

12.00
Unit II: 
Bio-Inorganic Chemistry

A brief introduction to bio-inorganic chemistry. Role of metal ions present in biological systems with special reference to Na+, K+ and Mg2+ ions: Na/K pump, role of Mg2+ ions in energy production and chlorophyll (Photosynthesis: PS-I and PS-II), role of Ca2+ in blood clotting, stabilization of protein structures and structural role in bones, Zn (Carboxypeptidase and Carbonic anhydrase- structure and function), metalloporphyrin with special reference to haemoglobin and myoglobin

11.00
Unit III: 
Polynuclear and heteronuclear aromatic compounds

Nomenclature, aromaticity, synthesis and reactivity of the following compounds with reference to electrophilic and nucleophilic substitution- naphthalene, anthracene, furan pyrrole , thiophene and pyridine.

6.00
Unit IV: 
Active methylene compounds:

Introduction, acidity of α- hydrogens, keto-enol tautomerism of ethyl acetoacetate, evidences in favour of keto-enol tautomerism, synthesis of ethylacetoacetate (Claisen condensation) alkylation reaction of ethylacetoacetate and its synthetic uses.

13.00
Unit V: 
Application of Spectroscopy to Simple Organic Molecules

Application of visible, ultraviolet and infrared spectroscopy in organic molecules.

Electromagnetic radiations, electronic transitions, λmax & εmax, chromophore, auxochrome, bathochromic and hypsochromic shifts. Application of electronic spectroscopy and Woodward rules for calculating  λmax of conjugated dienes and α,β – unsaturated compounds.

Infrared radiation and types of molecular vibrations, functional group and fingerprint region. IR spectra of alkanes, alkenes and simple alcohols (inter and intramolecular hydrogen bonding), aldehydes, ketones, carboxylic acids and their derivatives (effect of substitution on >C=O stretching absorptions)

Essential Readings: 
  • Organometallic Chemistry: A Unified Approach, Second Edition; R.C. Mehrotra and A. Singh; New Age International Private Limited, New Delhi, 2000.
  • Principles of Bioinorganic Chemistry, First Edition; S. J. Lippard, J.M. Berg; Panima Publishing Corporation, New Delhi, 2005.
  • Inorganic Chemistry (Principle of Structure and Reactivity), Fourth Edition; J. E Huheey, E. A. Keiter, R. L. Keiter; Pearson India, New Delhi, 2013.
  • Organic Chemistry, Sixth Edition; R. T. Morrison, R. N. Boyd; Pearson Education India, New Delhi, 2017.
  • Organic Chemistry, Vol. I , Sixth Edition; I.L. Finar; Pearson Education, New Delhi2002.
  • Spectrometric Identification of Organic Compounds, Eighth Edition; R.M. Silverstein, F.X. Webster, David J. Kiemie and David L. Bryce; John Wiley and Sons, Inc., Singapore, 2014.
References: 

 SUGGESTED READINGS:

  • Inorganic Chemistry, Seventh International Edition; M. Weller, T. Overton, J. Rourke, F. Armstrong; Oxford University Press, New York, 2018.
  • Inorganic Chemistry, Fifth Edition; G. L. Miessler and D. A. Tarr; Pearson Education Inc. Singapore, 2013.
  • Advanced Inorganic Chemistry, Sixth Edition; F.A. Cotton, G. Wilkinson, C.A. Murillo, M. Bochmann; John Wiley and Sons, USA, New York, 2007.
  • Organic Chemistry, Sixth Edition; G. Marc Loudon, J. Parise; WH Freeman, New York, 2015.
  • Spectroscopy of Organic Compounds, Sixth Edition; P.S. Kalsi; New Age International (P) Ltd Publishers, New Delhi, 2016.

e-RESOURCES:

 

 

Academic Year: 
2023-2024
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