Coming soon
Aromaticity and Stereochemistry
Course Objectives:
This course will enable the students to -
- Make the students understand the core concepts of organic chemistry, resonance, hyperconjugation, inductive effect etc. and other electronic effects including their qualitative and quantitative treatment.
- Provide an in-depth knowledge about the organic-chemical reactions with a focus on aromaticity &stereochemistry.
Course Outcomes (COs):
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Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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CHY 202 |
Aromaticity and Stereochemistry (Theory)
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The students will be able to – CO27: identify the different aromatic, non-aromatic, homoaromatic&antiaromatic compounds and interpret their properties. CO28: learn and identify many organic reaction mechanisms including electrophillic aromatic substitution. CO29: predict and describe various types of reactive intermediates, reactivity and factors affecting the reactivity and stability of aromatic substrates. CO30: apply the fundamental concepts of stereochemistry on simple molecules. |
Class lectures Tutorials Group discussions Peer teaching and learning Question preparation Subjective type Long answer Short answer Objective type Multiple choice questions One answer/two answer type questions Assertion and reasoning |
The oral and written examinations (Scheduled and surprise tests) Closed-book and open-book tests Problem-solving exercises Assignments Quiz Semester End Examination
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Pre requisite: Nomenclature of benzene derivatives (mono and disubstituted), physical properties
Introduction to aromatic compounds: Benzene, structure and stability, M.O. concept, resonance and resonance energy; aromaticity and Hückel’s (4n+2) rule, magnetic criteria.
Aromatic electrophilic substitution – general pattern of the mechanism, s and p complexes, energy profile diagram,activating and deactivating effects of substituents, orientation,o/p ratio, halogenation, nitration, sulphonation and desulphonation, FriedelCrafts alkylation and acylation; side chain halogenation of alkyl benzenes (toluene, ethyl benzene), Birch reduction
Self Study: Hydrogenation of benzene derivatives, industrial use of aromatic hydrocarbons.
Geometrical isomerism: Concept of restricted rotation – cis-trans, syn-anti and E,Z system of nomenclature, geometrical isomerism in oximes, amides and alicyclic compounds. Optical isomerism: Elements of symmetry, concept of asymmetry and chirality, enantiomers and diastereomers, racemic mixture and meso isomers; molecular chirality – allenes, relative and absolute configuration, nomenclature of optical isomers – D,L nomenclature, sequence rule and the R,S system of nomenclature, resolution of enantiomers; elementary concepts of asymmetric synthesis (concept of diastereomeric induction). Elementary concept of chiral induction through chemical reaction (reaction of bromine to alkane and alkenes)
Self Study: Physical properties of enantiomers and diastereomers, optical activity, polarized light, optical activity of enantiomers.
Nomenclature, method of preparation, chemical reactions, theory of strainless rings, cyclopropane and its reactivity with halogens.
Newman, Fischer, Sawhorse and Flying-wedge formula; conformation of ethane, n-butane and cyclohexane – axial and equatorial bonds, conformational analysis of monosubstituted and disubstituted cyclohexane (dimethyl cylcohexane), concepts of conformational locking; chair conformation of α and β glucose and their stability.
- Organic Chemistry; Fourth Edition, Indian Edition; G. Marc Loudon; Oxford University Press, New York,2008.
- Organic Chemistry; Sixth Edition; G. Marc Loudon, J. Parise; WH Freeman, New York, 2015.
- Stereochemistry: Conformation and Mechanism; Eighth Edition; P.S. Kalsi; New Age International Publishers Pvt Ltd, New Delhi, 2015.
- Organic Chemistry; Seventh Edition; R. T. Morrison, R. N. Boyd, S.K. Bhattacharjee; Pearson Education India, New Delhi, 2010.
- Stereochemistry of Organic compounds; First Edition; Ernest L. Eliel, Samuel H. Wilen; Wiley Interscience,1994.
