Bioinorganic Chemistry

Paper Code: 
CHY- 424(A)
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Objectives :

The course aims to make students understand the role of various elements in the living system, to acquire basic knowledge about the structure and functions of metalloenzymes and to know about the mechanism of binding interactions of metal complexes with biomolecules and metal based drug action.

 

Course Outcomes (COs):

 

                                                                                                                                  

COURSE

Learning outcomes (at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

CHY 424(A)

Bioinorganic Chemistry

The students will be able to-

 

CO143-apply the principles of coordination chemistry in biological systems.

CO144- describe ion pumps, mechanism of photosynthesis and role of calcium in biological systems

CO145- enumerate the structures and functions of various iron containing metalloproteins and describe the role of nitrogenases in the biological nitrogen fixation

CO146-explain the structures and functions of variety of metalloenzymes

CO147-discuss the toxicity and importance of metals in medicine.

CO148-discuss the various fundamental interactions of nucleic acids with metal ions. 

Class Lecture

 

Tutorials

 

Quiz

 

Problem solving

 

 

 

Group Discussion

 

Quiz

 

Assignment

 

PowerPoint Presentation

 

Semester End Exam

 

 
 

 

14.00
Unit I: 
Metal Ions in Living System
Introduction: Essential and trace elements, principles of coordination chemistry in biological systems, HSAB concept, chelate effect, Irving Williams series, pKa values of coordination ligands, tuning of redox potential, biopolymer effects, ligand exchange rates, substitution reactions, electrone transfer reactions.
 
Molecular mechanism –Ion transport across membranes, active transport of Na-K (ion pumps). Chlorophyll and their role in photosynthesis, (Calcium cycle and quantum efficiency) PS I and PS II system.
 
Calcium in Biological Systems: Calcium in living cells, transport and regulation of Ca+2 ions in higher organisms, molecular aspects of intramolecular processes, extracellular binding proteins.
 
13.00
Unit II: 
Iron in Biological Systems
Metal Storage and Transport: Structure and function of Ferritin, Transferrin, Siderophores, haemoglobin, myoglobin, haemocyanin and haemerythrin.
Electron transport proteins: Structure and function of cytochromes with special reference to cytochrome c, iron-sulphur proteins- Ferredoxins. Biological nitrogen fixation and its mechanism, nitrogenenases, dinitrogen complexes as models for nitrogen fixation.dioxygen model complexes of Fe, Co and Cu.
 
13.00
Unit III: 
Metalloenzymes
Zinc enzymes: Carboxypeptidase and carbonic anhydrase, alcoholic dehydrogenase.iron enzymes: Catalase, peroxidase and cytochrome P-450.copper enzymes: Superoxide dismutase,xanthine oxidase, vitamin B12 and B12 coenzymes.
 
8.00
Unit IV: 
Metals in Medicine
Fe, Zn and Cu deficiency, toxicity: Cu overload and wilson’s disease, iron toxicity, toxicity of As, Cd, Hg and Pb. Metal complexes in medicines, chelation therapy, BAL, penicilamine, poly amino carboxylic acid and desferrioxamine-gold compounds, rheumatoid arthritis, Pt complexes as anticancer drug, metal complexes in radiodiagnosis, MRI.
 
12.00
Unit V: 
Metal-Nucleic Acid Interactions
Basics- Nucleic acid structure, fundamental interactions and reactions with nucleic acids, applications of different metal complexes that binds nucleic acids, conformational probes, metal-nucleic acid interactions with special references to zinc finger protein.           
 
Essential Readings: 
  1. Principles of Bioinorganic Chemistry; First Edition; S. J. Lippard, J.M. Berg; Panima Publishing Corporation, New Delhi, 1995.
  2. Bioinorganic Chemistry; First, South Asian Edition; I.Bertini, H.B.Gray, S.J.Lippard; Viva Books Pvt Ltd., New Delhi, 1998.
  3. Bioinorganic Chemistry; First Edition; M.Satake, Y.Mido; Discovery Publishing House, New Delhi, 2003.
  4. Principles of Biochemistry;Third Edition; A. L. Lehninger, McMillan Press, London, 2002.

 

Academic Year: 
2019-2020
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