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Biomolecules
Paper Code:
CHY - 512
Credits:
3
Contact Hours:
45.00
Max. Marks:
100.00
7.00
Unit I:
Polynuclear Hydrocarbons
Structure, preparation, important reactions and derivatives of naphthalene, anthracene and phenanthrene.
10.00
Unit II:
Carbohydrates
Occurrence, classification and their biological importance
Monosaccharides: Constitution and absolute configuration of glucose and fructose, epimers and anomers, mutarotation, determination of ring size of glucose and fructose, Haworth projections and conformational structures; Interconversions of aldoses and ketoses; Killiani-Fischer synthesis and Ruff degradation.
Disaccharides – Structure of maltose, lactose and sucrose,α & β glycosidic linkages, reducing & non-reducing sugars
Polysaccharides – Elementary treatment of starch, cellulose and glycogen.
8.00
Unit III:
Nucleic Acids
Components of nucleic acids (DNA and RNA), nucleosides and nucleotides; double helical structure of DNA, Structure, synthesis and reactions of: Adenine, Guanine, Cytosine, Uracil and Thymine; Structure of polynucleotides.
8.00
Unit IV:
Amino acids, Peptides and Proteins
Amino acids, Peptides and their classification : α-Amino Acids - Synthesis, ionic properties and reactions. Zwitterions, pKa values, isoelectric point and electrophoresis;Glycoproteins.
Study of peptides: Determination of their primary structures-end group analysis, methods of peptide synthesis. Synthesis of peptides using N-protecting, C-protecting and C-activating groups . Solid-phase synthesis, denaturation and renaturation.
6.00
Unit V:
Lipids
Introduction to oils and fats; common fatty acids present in oils and fats, Hydrogenation of fats
and oils, Saponification value, acid value, iodine number. Reversion and rancidity.
Essential Readings:
- Organic Chemistry, Vol 2; Fifth Edition; I.L. Finar; Longman Scientific and Technical, Singapore, 1997.
- Organic Chemistry; Sixth Edition; Robert Thornton Morrison & Robert Neilson Boyd; Prentice-Hall of India Pvt. Ltd, New Delhi, 2004
- Principles of Biochemistry, Third Edition; A.L. Lehninger; McMillan Press, U.K, 2002
Academic Year:
