Biomolecules

Paper Code: 
CHY 512
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Course Objectives:

This course will enable the students to -

1.enable the learners to understand the basic processes which link the biological systems with the chemical systems.

 2. provide them with the basic knowledge and insight about the three-dimensional (3D) structure of macromolecules

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

Paper Code

Paper Title

 

 

 

 

 

CHY-512

Biomolecules

 

 

 

 

 

The students will be able to –

 

CO131: discuss the structures, preparations and chemical reactivities of polynuclear hydrocarbons

CO132: identify the chemical elements and functions of carbohydrates and interconvert & differentiate between simple and complex structures of the same.

CO133: sketch a detailed account of nucleic acids and their components with special emphasis on polynucleotides like DNA and RNA.

CO134: summarize the functions of amino acids, peptides & proteins and identify the influence of the threedimensional shape and subunits of a protein on its function.

CO135: acquire perspective on the composition and functioning of lipids with reference to their characteristic properties like iodine value, saponification, hydrogenation and reversion.

Interactive Lectures

 

Demonstrations

 

Discussions

 

Tutorials

 

Quiz

 

Problem solving

 

Continuous Assessment (Written test)

 

Quiz

 

Closed book and open-book tests

 

Assignment

 

Group Activity Semester End Exam

 

 

 

10.00
Unit I: 
Polynuclear Hydrocarbons

Structure, preparation, important reactions and derivatives of naphthalene, anthracene and phenanthrene.

12.00
Unit II: 
Carbohydrates

Occurrence, classification and their biological importance.

Monosaccharides: Constitution and absolute configuration of glucose and fructose, epimers and anomers, mutarotation, determination of ring size of glucose and fructose, Haworth projections and conformational structures; Interconversions of aldoses and ketoses; Killiani-Fischer synthesis and Ruff & Wohl degradation.

Disaccharides – Structure of maltose, lactose and sucrose, α & β glycosidic linkages, reducing & non-reducing sugars

Polysaccharides – Elementary treatment of starch, cellulose and glycogen.

8.00
Unit III: 
Nucleic Acids

Components of nucleic acids (DNA and RNA), nucleosides and nucleotides; Double helical structure of DNA. Structure, synthesis and reactions of: Adenine, Guanine, Cytosine, Uracil and Thymine; Structure of polynucleotides.

8.00
Unit IV: 
Amino acids, Peptides and Proteins

Amino acids, Peptides and their classification : α-Amino Acids - Synthesis, ionic properties and reactions. Zwitterions, pKa values, isoelectric point and electrophoresis; Glycoproteins.

Study of peptides: Determination of their primary structures-end group analysis, methods of peptide synthesis. Synthesis of peptides using N-protecting, C-protecting and C-activating groups . Solid-phase synthesis, denaturation and renaturation.

6.00
Unit V: 
Lipids

Introduction to oils and fats; Common fatty acids present in oils and fats, hydrogenation of fats and oils, saponification value, acid value, iodine number. Reversion and rancidity.

 

References: 
  • Organic Chemistry, Vol 2; Sixth Edition; I.L. Finar; Pearson Education, New Delhi, 2002.
  • Organic Chemistry; Seventh Edition; R. T. Morrison, R. N. Boyd, S.K. Bhattacharjee; Pearson Education India, New Delhi, 2010.
  • Lehninger Principles of Biochemistry; Seventh Edition; David L. Nelson, Michael M. Cox; W H Freeman,2017.
Academic Year: 
2020-2021
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