CHEMISTRY LAB VIII

Paper Code: 
CHY 515
Credits: 
2
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Objective(s):

This course will enable the students to –

  • provide knowledge of synthesis by conventional and non-conventional methods.
  • Be acquainted with the basic common laboratory techniques.

Course Outcomes (COs):

Course Outcomes

Teaching Learning Strategies

Assessment

Strategies

On completion of this course, the students will be able to-

CO151: demonstrate and apply common laboratory techniques including refluxing, distillation, recrystallization, vacuum filtration, extraction, thin layer chromatography in the prescribed synthesis

CO152: synthesize various organic compounds through conventional methods as well as green methods
  • Demonstrations
  • Peer learning
  • Interactive lectures
  • Problem solving exercise,
  • Handouts and manuals

 
  • Viva voce
  • Quiz
 

 

Unit I: 

 Basic techniques involved in synthetic organic chemistry                       60 Hrs

  1. Different types of glass wares
  2. Filtration
  3. Distillation (distillation at atmospheric pressure, steam distillation, fractional distillation and distillation at reduced pressure).
  4. Recrystallization and melting point correction.
  5. Use of decolourising carbon.
  6. Thin layer chromatography.

Synthesis (Green /Conventional))

  1. One step synthesis
  1. Aldol condensation :  Synthesis of dibenzal propanone  
  2. Acetylation  :  Synthesis of acetanilide from aniline
  3. Pechmann Condensation for Coumarin synthesis : Clay catalysed solid state synthesis of 7-hydroxy -4-methyl coumarin
  4. Diazotization : Preparation of Methyl orange/Methyl red
  5. Aromatic Electrophilic Substitution : Bromination of Phenol
  6. Rearrangement : Preparation of Phenytoin from Benzil and Urea

b. Two step synthesis

i. Benzoin → benzil → benzilic acid (calculation of atom economy required).
ii. Benzophenone → benzopinacol → benzopinacolone
iii. Acetanilide → p-bromoacetanilide → p-bromoaniline
iv. Acetanilide→ p-nitro acetanilide→ p-nitro aniline
v. Phthalic anhydride→  Phthalimide → Anthranilic Acid

 

Essential Readings: 
  • Vogel’s Textbook of Practical Organic Chemistry, Fifth Edition; B.S. Furniss, A.J. Hannaford, P.W.D. Smith, A.R. Tatchell; Pearson Education, New Delhi, 2003.
  • Monograph on Green Chemistry- Laboratory Experiments- Laboratory Task Force Committee , DST

 

References: 

  SUGGESTED READINGS:

  • University Practical Chemistry, Second Edition; P.C. Kamboj, Vishal Publishing House,New Delhi; 2019.

e-RESOURCES:

 

Marking Scheme

The duration of examination will be                                                        4 hrs.

The following exercises will be set in the examination

  • Organic Synthesis (one step)                                                           20 marks
  • Organic Synthesis (two step)                                                           35 marks
  • Viva                                                                                                  15 marks
  • Total                                                                                                 70 marks

A one step synthesis and a two-step Synthesis separately will be allotted to the candidates by lot. The yield, purity, crystallisation and recording of M.P. will be given due consideration while awarding marks.

Viva

Oral questions shall generally be asked over the work assigned to the candidate. The purpose is to find out as to what extent the candidate has understood the basic principles of chemistry.

Academic Year: 
2022-2023
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