Functionalized Organic Compounds-I

Pre requisite: S_N2 and S_N1 reactions, Saytzeff’s and Hoffmann rules.

Substitution reactions: introduction, stereochemistry and factors affecting reactivity in substitution reactions.
Elimination reactions: introduction, β elimination reactions – E₂ and E₁ reactions, orientation in β elimination reactions.
Substitution v/s elimination.
Self Study: Methods of preparation ,  other important reactions of alkyl halides.

Lack of reactivity of vinyl and aryl halide under S_N1 andS_N2 condition, elimination reaction of vinyl halide.
Nucleophilic substitution reaction of aryl halides: addition-elimination mechanism, elimination-addition (benzyne) mechanism; reactions involving allylic and benzyliccarbocations, allylic and benzylic S_N2 reactions.
 

Introduction, classification, methods of formation by reduction of aldehydes,  ketones, carboxylic acid and esters, biological oxidation of ethanol, hydrogen bonding, acidic nature-comparison with thiols, effect of solvents and polarity,reactions of alcohols.

Method of preparation, chemical reactions of vicinal glycols, oxidative cleavage with [Pb(OAc)₄] and HIO₄; Pinacol- pinacolone rearrangement.
Trihydric alcohols: introduction, method of preparation andchemical reactions of glycerol
Self Study: Nomenclature
 

Introduction, acidic character, comparative acidic strength of alcohol and phenol; reactions of phenols – electrophilic aromatic substitution, acylation and carboxylation, Fries rearrangement, Claisen rearrangement, Gattermann synthesis, Houben–Hoesch reaction, Lederer–Manasse reaction, Reimer-Tiemann reaction.
Self Study: Preparation of phenols.