Course Objectives:
This course will enable the students to –
learn how different compounds are prepared by the reactions of carbonyl moiety.
introduce how the reactivity can be explained to allow the introduction of functional group next to carbonyl group.
Course Outcomes (COs):
Course |
Learning outcomes (at course level) |
Learning and teaching strategies |
Assessment Strategies |
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Paper Code |
Paper Title |
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CHY 402
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Functionalized Organic Compounds-II (Carbonyl Compounds, Carboxylic Acids and its Derivatives)
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The students will be able to –
CO61: predict the reactivity of different carbonyl compounds (saturated and unsaturated aldehydes and ketones) and their methods of formation CO62: outline the nucleophilic addition reaction mechanism for carbonyl compounds CO63: interpret the mechanism and products in the prescribed name reactions following nucleophilic addition mechanism. CO64: explain the acidity and reactivity of active methylene groups CO65: describe the synthesis of carboxylic acids and its derivatives from different substrates CO66: justify the factors of the relative acidities of aliphatic and aromatic carboxylic acids by considering the inductive, resonance and steric effects on the neutral (conjugate acid) form and the anionic (conjugate base) form and compare with alcohols and phenols |
Interactive Lectures
Group Discussions
Tutorials
Quiz
Problem solving sessions
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Multiple choice questions
Assertions and reasoning
Short answer questions
Long answer questions
Assignments
Quiz
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Synthesis from acid chlorides, 1,3-dithianes and enamines, nitriles and carboxylic acids; mechanism of nucleophilic addition reaction to carbonyl group with particular emphasis on Benzoin, Perkin, aldol, Knoevenagel condensation, Reformatsky reaction and Dieckman condensation, condensation with ammonia & its derivatives including reactions with primary & secondary amines, Mannich & Wittig reactions.
Use of acetals as protecting groups. Oxidation of aldehydes, Baeyer-Villiger oxidation of ketones, Oppenauer oxidation, Cannizzaro’s reaction, MPV, Clemmensen, Wolff-Kishner, LiAlH4, NaBH4 reductions.
Introduction, acidity of α- hydrogens, keto-enoltautomerism of ethyl acetoacetate, evidences in favour of keto-enoltautomerism,synthesisofethylacetoacetate (Claisen condensation) and diethyl malonate, alkylation of ethylacetoacetate and diethyl malonate.
Pre requisite:Nomenclature, structure and physical properties, reduction of carboxylic acid to primary alcohol.
Acidity of carboxylic acids, effect of substituents on acidity; methods of preparation, reactions of carboxylic group, conversion of carboxylic acid into acid chlorides, anhydrides, amides, & esters, decarboxylation, Hell Volhard Zelinsky reaction.