Coming soon
Functionalized Organic Compounds-II (Carbonyl Compounds, Carboxylic Acids and its Derivatives)
To learn how different compounds are prepared by the reactions of carbonyl moiety and to introduce how the reactivity can be explained to allow the introduction of functional group next to carbonyl group.
Synthesis from acid chlorides, 1,3-dithianes and enamines, nitriles and carboxylic acids;mechanism of nucleophilic addition reaction to carbonyl group with particular emphasis on Benzoin,Perkin, aldol, Knoevenagel condensations,Reformatsky reaction and Dieckman condensation, condensation with ammonia & its derivatives including reactions with primary & secondary amines, Mannich & Wittig reactions.
Use of acetals as protecting groups.Oxidation of aldehydes,Baeyer-Villiger oxidation of ketones,Oppenauer oxidation.Cannizzaro’s reaction, MPV, Clemmensen,Wolff-Kishner, LiAlH4, NaBH4 reductions.
Introduction, acidity of α- hydrogens, keto-enol tautomerism of ethylacetoacetate, evidences in favour of keto-enol tautomerism, the Claisen condensation alkylation of diethyl malonate & ethylacetoacetate synthesis of ethylacetoacetate.
Pre requisite: Nomenclature, structure and physical properties, reduction of carboxylic acid to primary alcohol.
Acidity of carboxylic acids, effect of substituents on acidity; methods of preparation, reactions of carboxylic group, conversion of carboxylic acid into acid chlorides, anhydrides, amides, & esters, decarboxylation, Hell Volhard Zelinsky reaction.
Pre requisite: Nomenclature, preparation of carboxylic acid derivatives.
Basicity,relative stability of acyl derivative,physical properties , chemical reactions , mechanism of esterification & hydrolysis ( acid & base catalysed ) ,mechanism and reactivity in nucleophilic acyl substitution.
1. Organic Chemistry; Fourth Edition; G. Marc Loudon; Oxford University Press, New York, 2002.
2. Organic Chemistry; Sixth Edition; Robert Thornton Morrison & Robert Neilson Boyd; Prentice-Hall of India Pvt. Ltd , New Delhi, 2004.
