Introduction to Biomolecules

Paper Code: 
CHY- 125(B)
Credits: 
2
Contact Hours: 
30.00
Max. Marks: 
100.00
Objective: 

Course Objectives :

 

The course aims to enable the learners to understand the basic processes which link the biological systems with the chemical systems and to provide them with the basic knowledge and insight about the three-dimensional (3D) structure of macromolecules (protein and nucleic acids) and the relationship between their structure and function.

 

Course Outcomes (COs):

                                                                                                          

COURSE

Learning outcomes (at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

CHY 125(B)

Introduction to Biomolecules

The students will be able to-

 

CO28-describe the function of several important proteins and relate their function to the structure.

CO29-identify the chemical elements of carbohydrates and the difference between simple sugars and complex carbohydrates. 

CO30-discuss the relationship between cellular activities and biological responses. 

CO31-outline cell metabolism, chemical composition, physiochemical and functional organization of organelles.

CO32-illustrate the different composition and roles of nucleic acids in the cell and their interactions with each other.

CO33-analyze contemporary approaches and techniques used in modern cell and molecular biology. 

Interactive lectures

 

Discussions

 

Tutorials

 

Quiz

Written test

 

Google quiz

 

Assignment

 

Semester end examination
 

 

7.00
Unit I: 
The Matrix of Life

Origin of Life: elementary idea of prokaryotic and eukaryotic cell, difference between plant  and animal cell, cell organelles and their functions: plasma membrane, chloroplast, mitochondria, golgi bodies, endoplasmic reticulum, lysosomes, ribosomes, nucleus. Chemical bonds: Hydrogen bonds, covalent, ionic, van der Waals interactions.

 

 

6.00
Unit II: 
Proteins
Amino acids: Essential and non essential, structure of zwitterions, Synthesis of amino acids by reductive amination , GS-GOGAT system and transamination,
 
Structure of proteins: primary, secondary-α helix and β pleated sheets, tertiary and Quaternary structure.          
7.00
Unit III: 
Carbohydrates
Classification, structure and functions of monosaccharides, disaccharides, polysaccharides: starch, cellulose, glycogen, chitin and pectins.
 
Glycoconjugates: Proteoglycans, glycoproteins and glycolipids.                                                
5.00
Unit IV: 
Lipids
Structure and functions of lipids, saturated and unsaturated fatty acids, classification: simple, compound and derived lipids (steroids and cholesterol). Synthesis of long chain fatty acids, α-oxidation, β-oxidation.
 
5.00
Unit V: 
Nucleic Acids
DNA: Double helical structure of DNA, types of DNA -A, B, C and Z forms, replication.
 
RNA: RNA structure and its types- r RNA, mRNA, and tRNA, ribozymes.                              
 
Essential Readings: 
  1. Principles of Biochemistry; Third Edition; A.L. Lehninger;  McMillan Press Limited, London, 2002.
  2. Biochemistry; Fifth Edition; L. Stryer; W.H. Freeman and Company, 2002.
  3. Biochemistry; First Indian Reprint;J. D. Rawn;Tanima Publishing Corporation, New Delhi, 2004.
  4. Biochemistry; Second Edition; Voet and Voet;  John Wiley and Sons Inc., New York, 1995.
  5. Outline of Biochemistry; Fourth Edition; E.E. Conn and P.K. Stumpf; John Wiley and Sons Inc., New Delhi, 1994.
Academic Year: 
2019-2020
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