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Natural Products and Medicinal Chemistry | Chemistry

Natural Products and Medicinal Chemistry

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Paper Code: 
CHY 424 B
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

To learn the retrosynthesis and different classes of natural products for future endeavours in organic chemistry.

 

12.00
Unit I: 
Terpenoids and Carotenoids

Classification, nomenclature, occurrence, general methods of structure determination, isoprene rule; structure determination, stereochemistry and synthesis of the following representative molecules: Citral, Geraniol, Menthol and β-Carotene.

 

12.00
Unit II: 
Alkaloids

Definition, nomenclature, physiological action, occurrence, general methods of structure elucidation, degradation, classification based on nitrogen heterocyclic ring. Structure, stereochemistry and synthesis of the following: Ephedrine, (+)-Nicotine and Morphine.

 

12.00
Unit III: 
Steroids

Occurrence, nomenclature, basic skeleton, Diel’s hydrocarbon and stereochemistry. Structure determination and synthesis of Cholesterol, Androsterone, Testosterone, Estrone.

 

12.00
Unit IV: 
Medicinal Chemistry I

Introduction to drugs, discovery, development and delivery. Agonists and   antagonists.

Relation of Drug structure and its chemical and biological properties. Structure-activity and quantitative relationship. Drug targets.

 

12.00
Unit V: 
Medicinal Chemistry II

General introduction and  mode of action of- Anti-viral, antibiotics and anti-AIDS drugs.

Anti-inflammatory, analgesics, anti-histamines, anti-hypertensive and anti-cancer drugs.

General study of hormones, classification based on solubility and structures, mode of action of water soluble and fat soluble messengers.

 

References: 
  1. Introduction to Medicinal Chemistry, A Gringuage, Wiley-VCH
  2. Wilson and Gisvold’s Text Book of Organic Medicinal and Pharmaceutical Chemistry; Eleventh Edition; Lippincott Williams & Wilkins, 2004.
  3. An Introduction to Drug Design; S. S. Pandeya and J. R. Dimmock, New Age International.
  4. Burgers’s Medicinal Chemistry and Drug Discovery, Fifth Edition; M. E. Wolff, John Wiley and Sons, 1996.
  5. Goodmann and Gilman’s Pharmacological Basis of Therapeutics, Mc-Graw Hill.
  6. The Organic Chemistry of Drug Design and Drug Action, R. B. Silverman, Academic Press.
  7. Strategies for Organic Drug Synthesis and Design, D.Lednicer, John Wiley.

 

 

Academic Year: