Natural Products and Medicinal Chemistry

Paper Code: 
CHY 424 (B)
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

Course Objectives :

The course aims to describe the process of identification and isolation of natural products, their chemical synthesis, biological activities, ecological relevance and possible applications in the fields of pharmacology using selected examples. It also aims to introduce students with the fundamental concepts of drug discovery and development emphasizing specific classes of drugs.

Course Outcomes (Cos):                                                                                                                                 

COURSE

Learning outcomes (at course level)

Learning and teaching strategies

Assessment Strategies

Paper Code

Paper Title

CHY- 424(B)

Natural Products and Medicinal Chemistry

The students will be able to-

 

CO144- recognize various types of natural products along with their applications in medicinal chemistry.

CO145-explain the different techniques that are used in natural products chemistry as well as their structure elucidation.

CO146-describe the key concepts and strategies used during drug discovery, development and mode of action.

CO147-explain the importance of quantitative structure-activity relationship (QSAR) as a potential source for rational drug design in brief.

Interactive Lectures

 

Discussion

 

Tutorials

 

Problem Solving

 

Power Point Presentation

Quiz

 

Assignments

 

Written Test

 

Semester End Exam
 

 

12.00
Unit I: 
Terpenoids and Carotenoids

Classification, nomenclature, occurrence, general methods of structure determination, isoprene rule; structure determination, stereochemistry and synthesis of the following representative molecules:Citral, Geraniol, Menthol and β-Carotene.

12.00
Unit II: 
Alkaloids

Definition, nomenclature, physiological action, occurrence, general methods of structure elucidation, degradation, classification based on nitrogen heterocyclic ring. Structure, stereochemistry and synthesis of the following: Ephedrine, (+)-Nicotine and Morphine.

12.00
Unit III: 
Steroids

Occurrence, nomenclature, basic skeleton, Diel’s hydrocarbon and stereochemistry. Structure determination and synthesis of Cholesterol, Androsterone, Testosterone, Estrone.

12.00
Unit IV: 
Medicinal Chemistry I

Introduction to drugs, discovery, development and delivery. Agonists and  antagonists.Relation of Drug structure and its chemical and biological properties. Structure-activity and quantitative relationship. Drug targets.

12.00
Unit V: 
Medicinal Chemistry II

General introduction and  mode of action of- antiviral, antibiotics and anti-AIDS drugs.

Anti-inflammatory, analgesics, antihistamines, anti-hypertensive and anti-cancer drugs.

General study of hormones, classification based on solubility and structures, mode of action of water soluble and fat-soluble messengers.

References: 
  • Introduction to Medicinal Chemistry: First Edition,A Gringauz, Wiley-VCH, 1996
  • Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry; Twelfth Edition,Wolters Kluwer India Pvt. Ltd., 2010.
  • An Introduction to Drug Design; Second Edition, S. N. Pandeya and J.R. Dimmock, New Age International, 2019.
  • Burgers’s Medicinal Chemistry and Drug Discovery; Sixth Edition, D.J. Abraham, Wiley-Blackwell, 2003.
  • Goodmann and Gilman’s Pharmacological Basis of Therapeutics; Thirteenth Edition, Laurence L. Brunton, Mc-Graw Hill, 2017.
  • The Organic Chemistry of Drug Design and Drug Action; Third Edition, R. B. Silverman, Academic Press, 2014.
  • Strategies for Organic Drug Synthesis and Design; Second Edition, D. Lednicer, Wiley-Blackwell, 2008

 

Academic Year: 
2020-2021
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