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It is a University which is committed to excellence and overall development of the student and one where talent is nurtured and honed in the best possible manner. Come, be a part of our never-ending journey of accomplishments and accolades.

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IIS Univ
  • Admissions

    It is a University which is committed to excellence and overall development of the student...

  • Placements

    Excellent education not only imparts knowledge, but also paves the way for...

  • Life@IIS Univ

    Life @ IISU is nothing less than a kaleidoscope of myriad hues; complete with...

  • Academics

    Taking the age-old tradition of enlightenment through education forward,...

  • Research

    To stimulate curiosity and cater to the global needs of a dynamic education,...

  • About Us

    The IIS University, with its perfect amalgamation of innovation, inspiration...

IIS (Deemed to be University)

Gurukul Marg, SFS, Mansarovar, Jaipur 302020, (Raj.) India

Phone:- +91-141-2400160-61, 2397906-07,

Fax: 2395494,2781158, Toll Free No.: 1800 180 7750

Natural Products and Medicinal Chemistry | Chemistry

Natural Products and Medicinal Chemistry

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Paper Code: 
25CHY424B
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to

describe the process of identification and isolation of natural products, their chemical synthesis, biological activities, ecological relevance and possible applications in the fields of pharmacology using selected examples. It also aims to introduce students with the fundamental concepts of drug discovery and development emphasizing specific classes of drugs.

 

 

Course Outcomes: 

Course

Learning outcome

(at course level)

Learning and Teaching Strategies

Assessment Strategies

Course Code

Course

Title

 

25CHY424 B

 

Natural Products and Medicinal Chemistry (Theory)

CO170 Discuss the structure,  properties and stereochemistry of prescribed terpenoids & carotenoids.

CO171 Explain different techniques   used for the structure elucidation of alkaloids along with the structure and physiological actions of the stipulated alkaloids.

CO172 Deduce the structure of complex natural products like steroids and appraise their biological properties.

CO173 Describe the key concepts and strategies used during drug discovery, development and mode of action.

CO174 Explain            the importance of quantitative structure-activity relationship (QSAR) as a potential source for rational drug design in brief.

CO175 Contribute effectively in course-specific interaction.

Approach in teaching:

Interactive lectures, tutorials, group discussions and e-learning.

 

Learning activities for the students:

Peer learning, e- learning, problem solving through tutorials and group discussions.

 

 

Written examinations,

Assignments, Quiz

 

 

12.00
Unit I: 
Terpenoids & Carotenoids

Classification,nomenclature,occurrence,generalmethodsofstructuredetermination,isoprene rule; Structure determination, stereochemistry and synthesis of the following representative molecules- citral, geraniol, menthol andβ-Carotene.

 

12.00
Unit II: 
Alkaloids

Definition, nomenclature, physiological action, occurrence, general methods of structure elucidation, degradation, classification based on nitrogen heterocyclic ring. Structure, stereochemistry and synthesis of the following: Ephedrine, (+)-Nicotine and Morphine.

 

12.00
Unit III: 
Steroids

Occurrence, nomenclature, basic skeleton, Diels- hydrocarbon and stereochemistry. Structure

determination and synthesis of cholesterol, androsterone, testosterone, estrone.

 

 

12.00
Unit IV: 
Medicinal Chemistry I

Introduction to drugs, discovery, development and delivery, agonists and antagonists, relation of drug structure and its chemical and biological properties.

Structure-activity and quantitative relationship. Drug targets.

 

12.00
Unit V: 
Medicinal Chemistry II

General introduction and mode of action of- antiviral, antibiotics and anti-AIDS drugs, anti-inflammatory, analgesics, antihistamines, anti-hypertensive and anti-cancer drugs.

General study of hormones, classification based on solubility and structures, mode of action of water soluble and fat-soluble messengers.

 

Essential Readings: 
  1. Organic Chemistry, Vol II; Sixth Edition; I.L. Finar; Pearson Education, New Delhi, 2013.
  2. Wilson and Gisvold’s Textbook of Organic Medicinal and Pharmaceutical Chemistry, Twelfth Edition, Wolters Kluwer India Pvt. Ltd., 2010.
  3. Burgers’s Medicinal Chemistry and Drug Discovery, Sixth Edition, D.J. Abraham, Wiley- Blackwell, 2003.

 

References: 
  1. Introduction to Medicinal Chemistry, First Edition; A Gringauz, Wiley-VCH, 1996.
  2. Organic Chemistry, Sixth Edition; R. T. Morrison, R. N. Boyd; Pearson Education India, New Delhi, 2017.
  3. An Introduction to Drug Design, Second Edition, S. N. Pandeya and J.R. Dimmock, New Age International, 2019.
  4. Goodmann and Gilman’s Pharmacological Basis of Therapeutics, Thirteenth Edition, Laurence L. Brunton, Mc-Graw Hill, 2017.
  5. The Organic Chemistry of Drug Design and Drug Action, Third Edition, R. B. Silverman, Academic Press, 2014.
  6. Strategies for Organic Drug Synthesis and Design, Second Edition; D. Lednicer, Wiley-Blackwell, 2008.

 

e-Resources:

  1. http://oms.bdu.ac.in/ec/admin/contents/1_16SCCCH8_2020051904202312.pdf (Natural Products)
  2. http://www.pharmacy180.com/group/medicinal-chemistry-6/ (Medicinal Chemistry)

 

 

 

Academic Year: 
2025-2026
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