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Nitrogen containing functional groups, Natural products and Drugs
Paper Code:
CHY - 412
Credits:
3
Contact Hours:
45.00
Max. Marks:
100.00
9.00
Unit I:
Nitrogen Containing Functional Groups
Preparation and important reactions of nitro compounds, nitriles and isonitriles
Amines: Effect of substituent and solvent on basicity; Preparation and properties: Gabriel phthalimide synthesis, Hoffmann bromamide reaction, Carbylamine reaction, Mannich reaction, Hoffmann’s exhaustive methylation, Hofmann-elimination reaction; Distinction between 10, 20 and 30 amines with Hinsberg reagent and nitrous acid, amines as phase transfer catalyst.
7.00
Unit II:
Synthetic Dyes
Diazonium Salts: Preparation and their synthetic applications. Colour and constitution (electronic concept), classification of dyes, chemistry and synthesis of methyl orange, congo red, malachite green, crystal violet, phenolphthalein, fluorescein, alizarin and indigo.
10.00
Unit III:
Heterocyclic Compounds
Classification and nomenclature, Structure, aromaticity in 5-membered and 6-membered rings
containing one heteroatom; Synthesis, reactions and mechanism of substitution reactions of: Furan, Pyrrole, Thiophene, Pyridine, Pyrimidine, Indole, quinoline and isoquinoline,
10.00
Unit IV:
Alkaloids and Terpenoids
Alkaloids
Natural occurrence, General structural features, Isolation and their physiological action, Emde’s modification, Structure elucidation and synthesis of Nicotine. Medicinal importance of Nicotine, Hygrine, Quinine, Morphine, Cocaine, and Reserpine.
Terpenes
Occurrence , classification, isoprene rule; Elucidation of structure and synthesis of Citral and α- terpineol.
9.00
Unit V:
Pharmaceutical Compounds: Structure and Importance
Classification, structure and therapeutic uses of antipyretics: Paracetamol (with synthesis), Analgesics: Ibuprofen (with synthesis), Phenacetin, Aspirin, Antimalarials: Chloroquine (with synthesis). An elementary treatment of Antibiotics and detailed study of chloramphenicol .Mechanism of Drug Action( brief idea), Sulpha drugs: sulphadiazine (sulpha pyrimidine), sulpha guanidine, sulpha methazine, sulpha pyridine.
Essential Readings:
- Organic Chemistry, Vol 2; Fifth Edition; I.L. Finar; Longman Scientific and Technical, Singapore, 1997.
- Principles of Biochemistry, Third Edition; A.L. Lehninger; McMillan Press, U.K, 2002.
Academic Year:
