ORGANIC CHEMISTRY LAB II

Paper Code: 
CHY 327
Credits: 
3
Contact Hours: 
90.00
Max. Marks: 
100.00
Objective: 

Course Objective(s) :

This course will enable the students to –

acquire knowledge of synthesis by conventional and non-conventional methods, handling of hazardous chemicals and to enhance learning of physical and spectroscopic techniques.

Course Outcomes (COs):

Course Outcomes

Teaching Learning Strategies

Assessment Strategies

On completion of this course, students will be able to-

CO106:characterize organic molecules by physical and spectroscopic methods including mp, bp, IR, NMR and chromatography.

CO107:demonstrate and apply common laboratory techniques, including refluxing, distillation, steam distillation, recrystallization, vacuum filtration, extraction, thin layer chromatography, column chromatography in the specific synthesis etc.

CO108:employ spectrophotometric techniques for the estimations of prescribed biomolecules.
  • Laboratory instructions and Demonstrations

 
  • Conduction of Experiments
  • Lab Records
  • Viva voce

 

 

 
 


 

 

Unit I: 

Synthesis (Green Methods / Conventional Methods)

  1. One step synthesis
    • Aldol condensation (Synthesis of dibenzal propanone)
    • Acetylation (synthesis of acetanilide from aniline)
    • Pechmann Condensation for Coumarin synthesis (Clay catalyzed solid state synthesis of 7- hydroxy -4-methyl coumarin)
    • Bromination of phenol
  1. Two step synthesis (any three)
    • Benzoin → benzil → benzilic acid
    • Benzophenone → benzopinacol → benzopinacolone
    • Acetanilide → p-bromoacetanilide → p-bromoaniline
    • Acetanilide → p-nitroacetanilide → p-nitroaniline
    • Resorcinol → fluorescein → eosin
    • Phthalic anhydride → phthalimide → anthranilic acid

Extraction of Organic Compounds from Natural Resources (any three)

  • Isolation of caffeine from tea leaves.
  • Isolation of casein from milk.
  • Isolation of lactose from milk.
  • Isolation of nicotine dipicrate from tobacco.

Spectroscopy

Identification of organic compounds (with emphasis on isomeric studies and calculation of % ratio of tautomers) by the spectral analysis.

Spectrophotometric Estimations (any three)

  • Protein
  • Carbohydrate
  • Cholesterol
  • Phosphate
  • Ascorbic acid

 

Essential Readings: 
  • Vogel’s Textbook of Practical Organic Chemistry, Fifth Edition, B.S. Furniss, A.J. Hannaford, P.W.G. Smith, A.R. Tatchell; Addison – Wesley Publishing Company, 2014.
  • Practical Organic Chemistry, Fourth Edition; F.C. Mann and B.C. Saunders; Pearson Education, New Delhi, 2013.
     

 

References: 

SUGGESTED READINGS:

  • Advanced Practical Organic Chemistry, J. Leonard, B. Lygo and G. Procter; Third Edition; CRC Press, 2013.

e-RESOURCES:

Scheme of Examination

The duration of examination will be 6 hrs.
The following exercises will be set in the examination
Organic Synthesis                                                          26 marks
Spectral Problems                                                          14 marks
Spectrophotometric Estimation                                        15 marks
Viva                                                                             15 marks
Total                                                                               70 marks

1.Organic synthesis

This exercise carries 26 marks. Either 2 one step synthesis or two step synthesis will be allotted to the candidates by lot. The yield, purity, crystallization and recording of m.p. will be given due consideration while awarding marks.     

2.Spectral Problems

This exercise carries 14 marks. The students may be provided with either spectral problems or data base problems.

3.Spectrophotometric Estimation

This exercise carries 15 marks. Three marks are reserved for the preparatory work, setting up of an instrument and experimental skills. The distribution of remaining 12 marks are as follows.

Correct observation and proper recording                                     4 marks
Standard curve                                                                          4 marks
Result                                                                                       4marks

4.Viva

Oral questions shall generally be asked over the work assigned to the candidate. The purpose is to find out as to what extent the candidate has understanding the basic principles of chemistry.

 

 

Academic Year: 
2023-2024
  • Printer-friendly version
  • PDF version