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Organometallics, Bioinorganic Chemistry, Polynuclear Hydrocarbons and UV, IR Spectroscopy
This course will enable the students to
understand about the basics of organometallic chemistry, structure and nature of bonding in metal carbonyls and gain an in-depth knowledge about vitality of different types of metal ions in biosystems
enrich the ability to compare the effect of heteroatoms on structure and reactivity of simple and polynuclear aromatic compounds and apply the key concepts of IR and UV spectroscopy in the structure elucidation of various known and unknown organic molecules.
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Course Code |
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24DCHY 501(A) |
Organometallics, Bioinorganic Chemistry, Polynuclear Hydrocarbons and UV, IR Spectroscopy (Theory)
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CO48: Describe organometallic compounds , their nomenclature, properties and stability. CO49: Differentiate between bulk and trace elements, explain the importance of metal ions in biological systems. CO50: Describe the structural and chemical properties of five and six membered aromatic heterocycles and active methylene groups CO51: Calculate the λmax for different organic compounds using Woodward-Fieser rule. CO52: Relate the theoretical knowledge & selection rules of IR to the spectral analysis of simple compounds. CO53: Contribute effectively in course-specific interaction. |
Approach in teaching: Interactive lectures, tutorials, group discussions and e-learning.
Learning activities for the students: Peer learning, e- learning, problem solving through tutorials and group discussions.
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Written examinations, assignments and quiz.
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Transition Metals: Preparation and important properties of the following compounds-Peroxo compounds of Cr, K2Cr2O7, KMnO4, K4[Fe(CN)6], sodium nitroprusside, [Co(NH3)6]Cl3, Na3[Co(NO2)6].
Organometallic Compounds: Definition, nomenclature and classification of organometallic compounds; Hapticity(η) of organometallic ligands, 18-electron rule. Preparation, properties and structure of alkyls and aryls of Li.
Structure and bonding in metal ethylenic complex–Zeise’s salt (η2) and metal cyclopentadienyl complex- Ferrocene(η5).
Introduction to π acceptor ligands, definition, classification, general methods of preparation, properties, structure and nature of bonding (Synergic effect: VB approach and MO approach) in mononuclear carbonyls.
A brief introduction to bio-inorganic chemistry. Role of metal ions present in biological systems with special reference to Na+, K+ and Mg2+ ions: Na/K pump, role of Mg2+ ions in energy production and chlorophyll (Photosynthesis: PS-I and PS-II), role of Ca2+ in blood clotting, stabilization of protein structures and structural role in bones, Zn (Carboxypeptidase and Carbonic anhydrase- structure and function), metalloporphyrin with special reference to haemoglobin and myoglobin.
Nomenclature, aromaticity, synthesis and reactivity of the following compounds with reference to electrophilic and nucleophilic substitution- naphthalene, anthracene, furan pyrrole , thiophene and pyridine.
Introduction, acidity of α- hydrogens, keto-enol tautomerism of ethyl acetoacetate, evidences in favour of keto-enol tautomerism, synthesis of ethylacetoacetate (Claisen condensation) alkylation reaction of ethylacetoacetate and its synthetic uses.
Application of visible, ultraviolet and infrared spectroscopy in organic molecules.
Electromagnetic radiations, electronic transitions, λmax & εmax, chromophore, auxochrome, bathochromic and hypsochromic shifts. Application of electronic spectroscopy and Woodward rules for calculating λmax of conjugated dienes and α,β – unsaturated compounds.
Infrared radiation and types of molecular vibrations, functional group and fingerprint region. IR spectra of alkanes, alkenes and simple alcohols (inter and intramolecular hydrogen bonding), aldehydes, ketones, carboxylic acids and their derivatives (effect of substitution on >C=O stretching absorptions).
- Organometallic Chemistry: A Unified Approach, Second Edition; R.C. Mehrotra and A. Singh; New Age International Private Limited, New Delhi, 2000.
- Principles of Bioinorganic Chemistry, First Edition; S. J. Lippard, J.M. Berg; Panima Publishing Corporation, New Delhi, 2005.
- Inorganic Chemistry (Principle of Structure and Reactivity), Fourth Edition; J. E Huheey, E. A. Keiter, R. L. Keiter; Pearson India, New Delhi, 2013.
- Organic Chemistry, Sixth Edition; R. T. Morrison, R. N. Boyd; Pearson Education India, New Delhi, 2017.
- Organic Chemistry, Vol. I , Sixth Edition; I.L. Finar; Pearson Education, New Delhi2002.
- Spectrometric Identification of Organic Compounds, Eighth Edition; R.M. Silverstein, F.X. Webster, David J. Kiemie and David L. Bryce; John Wiley and Sons, Inc., Singapore, 2014.
- Inorganic Chemistry, Seventh International Edition; M. Weller, T. Overton, J. Rourke, F. Armstrong; Oxford University Press, New York, 2018.
- Inorganic Chemistry, Fifth Edition; G. L. Miessler and D. A. Tarr; Pearson Education Inc. Singapore, 2013.
- Advanced Inorganic Chemistry, Sixth Edition; F.A. Cotton, G. Wilkinson, C.A. Murillo, M. Bochmann; John Wiley and Sons, USA, New York, 2007.
- Organic Chemistry, Sixth Edition; G. Marc Loudon, J. Parise; WH Freeman, New York, 2015.
- Spectroscopy of Organic Compounds, Sixth Edition; P.S. Kalsi; New Age International (P) Ltd Publishers, New Delhi, 2016.
e-Resources:
- https://nptel.ac.in/courses/104101091 (Unit I)
- https://nptel.ac.in/courses/104108062 (Unit I)
- https://egyankosh.ac.in/bitstream/123456789/85316/3/Block-2.pdf (Unit III)
- https://egyankosh.ac.in/bitstream/123456789/83052/3/Block-1.pdf (Unit II)
- https://www.arsdcollege.ac.in/wp-content/uploads/2020/03/Active-methylene-compound-EAA.pdf(Unit IV)
- https://www.youtube.com/watch?v=qqylkUqd12s (Unit V)
- https://www.youtube.com/watch?v=_TmevMf-Zgs (Unit V)
