Apply Online
IIS University

Admissions

It is a University which is committed to excellence and overall development of the student and one where talent is nurtured and honed in the best possible manner. Come, be a part of our never-ending journey of accomplishments and accolades.

Psychometric Counselling Tele-Counselling E-mail Counselling Subject Counselling International Admissions
Placement Placements Go Down
Life@IIS Univ Life@IIS Univ Go Down
Academics Go Down
Research Go Down
About-Us Go Down
University Status

Admissions

It is a University which is committed to excellence and overall development of the student and one where talent is nurtured and honed in the best possible manner. Come, be a part of our never-ending journey of accomplishments and accolades.

Read More

Placements

Excellent education not only imparts knowledge, but also paves the way for a promising and successful career. The Placement Cell at The IIS University has numerous success stories to narrate in this regard...

Read More

Life@IIS Univ

Life @ IISU is nothing less than a kaleidoscope of myriad hues; complete with vibrant events and memorable occasions to cherish for a lifetime.

Read More

Academics

Taking the age-old tradition of enlightenment through education forward, The IIS University - in its continuous pursuit of excellence - firmly believes that an institution’s academic profile determines its worth and value. Therefore, on offer are a wide variety of both conventional and contemporary programmes of study.

Read More

Research

To stimulate curiosity and cater to the global needs of a dynamic education, The IIS University - since inception - has been promoting and encouraging research-based experiential learning among all its students.

Read More

About Us

The IIS University, with its perfect amalgamation of innovation, inspiration and synergy, aims to be a model institution for students across disciplines and programmes.

Read More
IIS Univ
  • Admissions

    It is a University which is committed to excellence and overall development of the student...

  • Placements

    Excellent education not only imparts knowledge, but also paves the way for...

  • Life@IIS Univ

    Life @ IISU is nothing less than a kaleidoscope of myriad hues; complete with...

  • Academics

    Taking the age-old tradition of enlightenment through education forward,...

  • Research

    To stimulate curiosity and cater to the global needs of a dynamic education,...

  • About Us

    The IIS University, with its perfect amalgamation of innovation, inspiration...

IIS (Deemed to be University)

Gurukul Marg, SFS, Mansarovar, Jaipur 302020, (Raj.) India

Phone:- +91-141-2400160-61, 2397906-07,

Fax: 2395494,2781158, Toll Free No.: 1800 180 7750

Synthetic Strategies in Organic Chemistry | Chemistry

Synthetic Strategies in Organic Chemistry

Error message

  • Warning: ini_set(): Headers already sent. You cannot change the session module's ini settings at this time in drupal_environment_initialize() (line 691 of /home/iisunivac/public_html/includes/bootstrap.inc).
  • Warning: ini_set(): Headers already sent. You cannot change the session module's ini settings at this time in drupal_environment_initialize() (line 692 of /home/iisunivac/public_html/includes/bootstrap.inc).
  • Warning: ini_set(): Headers already sent. You cannot change the session module's ini settings at this time in drupal_environment_initialize() (line 693 of /home/iisunivac/public_html/includes/bootstrap.inc).
  • Warning: ini_set(): Headers already sent. You cannot change the session module's ini settings at this time in drupal_environment_initialize() (line 698 of /home/iisunivac/public_html/includes/bootstrap.inc).
  • Warning: ini_set(): Headers already sent. You cannot change the session module's ini settings at this time in drupal_environment_initialize() (line 702 of /home/iisunivac/public_html/includes/bootstrap.inc).
Paper Code: 
25CHY426B
Credits: 
4
Contact Hours: 
60.00
Max. Marks: 
100.00
Objective: 

This course will enable the students to

gain advanced knowledge in synthetic organic and green chemistry so that the learner can suggest alternative reagents and reactions for performing desired organic transformations.

 

Course Outcomes: 

Course

Learning outcome

(at course level)

Learning and Teaching Strategies

Assessment Strategies

Course Code

Course

Title

 

25CHY426B

 

Synthetic Strategies in Organic Chemistry (Theory)

CO182 Plan an organic synthesis using suitable reagents to understand a range of more sophisticated approaches to synthesis (building on the knowledge from previous years).

CO183 Apply reduction methods  involving main group and transition metal reagents for the synthesis of complex organic compounds.

CO184 Predict the newer synthetic tools for the selection of one type of reagent and reaction conditions over another in terms of efficacy in relation to a particular synthetic problem.

CO185 Solve the mechanistic problems in a facile manner using the prescribed organocatalysts.

CO186 Analyze the environmental impacts of chemistry and apply the green chemical tools, for cleaner environment and energy.

CO187 Contribute effectively in course-specific interaction.

Approach in teaching:

Interactive lectures, tutorials, group discussions and e-learning.

 

Learning activities for the students:

Peer learning, e- learning, problem solving through tutorials and group discussions.

 

 

Written examinations,

Assignments, Quiz

 

 

14.00
Unit I: 
Oxidation Reactions

Metal-based and non-metal based oxidations of-

  1. Alkenes to alcohols/carbonyls-hydroboration-oxidation, chiral boranes, Wacker oxidation,          SeO2/ selenium oxidants, chromium based oxidation.
  2. Alkenes to epoxides (peroxides/per acids based)-Sharpless asymmetric epoxidation, Jacob- Katsuki epoxidation, Shi epoxidation.
  3. Alkenes to diols (manganese, osmium based)- Sharpless asymmetric dihydroxylation,                Prevost reaction and Woodward modification.
  4. Ketones to ester/lactones- Baeyer- Villiger.
  5. Alcohols to carbonyls- Corey-Kim oxidation, Dess-Martin oxidation, Swern oxidation.             Manganese, aluminium, hypervalent iodine and TEMPO based reagents.

 

12.00
Unit II: 
Reduction Reactions
  1. Catalytic hydrogenation (Homogeneous hydrogenation: Wilkinson, Noyori asymmetric             hydrogenation, stereo and enantioselective hydroboration.
  2. Metal based reductions: Li and Na in liquid ammonia, Birch reduction, Mc Murry, acyloin             formation
  3. Hydride transfer reagents.
  4. NaBH4, triacetoxyborohydride, L-selectride, K-selectride, Luche reduction; LiAlH4, DIBAL-H,         and Red-Al, trialkylsilanes and trialkylstannane, Meerwein-Pondorff-Verley reduction,             Clemmensen and Wolff-Kishner reduction.

 

13.00
Unit III: 
Newer Synthetic Reactions-I
  1. Metal mediated C- C and C-X coupling reactions: Suzuki, Heck. Stille, Sonogashira cross             coupling, Buchwald-Hartwig amination and Negishi, Kumada coupling reactions. Umpolung.
  2. C=C Formation Reactions: Wittig reactions and its modifications, Shapiro, Bamford-            Stevens. Julia-Lythgoe olefination and Peterson’s stereoselective olefination, phosphorus,             sulphur and nitrogen ylides, Stork-enamine reaction.
  3. Multicomponent Reactions: Mannich, Biginelli, Hantzsch, Passerini. Ugi reaction.

 

10.00
Unit IV: 
Newer Synthetic Reactions-II
  1. Ring Formation Reactions: Pausan-Khand reaction, Bergman cyclisation, Nazarov             cyclisation.
  2. Click Chemistry: Criteria for Click reaction, Sharpless azide cycloadditions.
  3. Olefin metathesis: Shrock’s, Grubb’s 1st and 2nd generation catalyst. Grubb-Hoveyda catalyst, olefin cross metathesis (OCM), ring closing metathesis (RCM), ring opening             metathesis (ROM) and applications.

 

 

11.00
Unit V: 
Organocatalysis

Definition, generic modes, classification.

Covalent organocatalysis : Secondary amines via enamine, imine, imim ion, amidines, guanidines, Lewis base catalysis, nitrogen heterocyclic carbenes (NHC), synthesis, structure, catalysis-homo-and cross-benzoin condensation, Stetter reaction, hydrosilylation of styrenes, transesterification.

Noncovalent organocatalysis, hydrogen bonding catalysis, thiourea based catalysts, Diols- TADDOL.

Phosphorus containing organocatalysts: Triphenylphosphine, Binol-derived phosphoric acids, cyclic diphosphazanes, phosphonates.

 

Essential Readings: 
  1. Organic Chemistry, Second edition; J. Clayden, N. Greeves, S. Warren; Oxford University Press, United Kingdom, 2012.
  2. Advanced Organic Chemistry: Reactions, Mechanisms and Structure, Seventh Edition; J. March; John Wiley and Sons Asia Private Limited, New Delhi, 2015.

 

References: 
  1. Advanced Organic Chemistry Part A & B, Fifth Edition; F. A. Carey and R. J. Sundberg; Springer, US, 2007.
  2. A Guidebook to Mechanism in Organic Chemistry, Sixth Edition; P. Sykes; Pearson Education, Delhi, 2011.
  3. Reaction Mechanism in Organic Chemistry, Third Edition; S. M. Mukherjee and S. Singh; Macmillan India Ltd., New Delhi, 2003.
  4. Mechanism and Theory in Organic Chemistry; Third Edition; T.H. Lowry; Addison– Wesley Publishing Company, 1999.
  5. Organic Chemistry; Fifth Edition; S.H. Pine; Tata McGraw Hill Publishing Company,2007.
  6. Modern Methods of Organic Synthesis; Fourth Edition; W. Carruthers; Cambridge Univ. Press, UK, 2005.
  7. Principles of Asymmetric Synthesis; Second Edition; R. Gawley and J. Aube; New York: Pergamon Press, 2012.

 

e-Resources:

  1. https://hwpi.harvard.edu/files/myers/files/6-oxidation.pdf (Oxidation Reactions)
  2. https://www.vanderbilt.edu/AnS/Chemistry/Rizzo/chem223/Oxidations.pdf (Oxidation Reactions)
  3. https://hwpi.harvard.edu/files/myers/files/5-reduction.pdf (Reduction Reactions)
  4. https://nptel.ac.in/courses/104103067 (Organocatalysis)
  5. https://application.wiley-vch.de/books/sample/352730715X_c01.pdf (Green Chemistry)

 

Academic Year: 
2025-2026
  • Printer-friendly version
  • PDF version