Nomenclature of five and six membered heterocycles; molecular orbital picture and aromatic character of pyrrole , pyridine, furan and thiophene; methods of synthesis, chemical reactions with respect to electrophilic substitution reactions, nucleophilic substitution reactions in pyridine and pyrrole (mechanism and orientation), comparision ofbasicity of pyridine peperidineand pyrrole.

Preparation and reactions of indole, quinoline and isoquinoline with special reference to Fischer indole synthesis, Skraup synthesis and Bischler – Napieralski synthesis.

Pre requisite: Aliphatic nitro compounds.

Preparation, reactions – electrophilic and nucleophilic substitution, effect of the substituents on the acidity of phenols, effect of nitro group on nucleophilic substitution of aryl halides, reduction.

Nomenclature,preparation and reactions of aliphatic and aromatic primary amines.

Classification and distinction between primary, secondary and tertiary amines; relative basic strength of aliphatic and aromatic amines; diazotization- mechanism, stability of diazonium salts,

Self Study:diazo coupling

Introduction, lock and key theory

Synthesis and medicinal applications of -Sulpha drugs: sulphadiazine (sulpha pyrimidine), sulpha guanidine, sulphamethazine, sulpha pyridine.

Analgesics: aspirin, phenacetin, paracetamol.

Antimalarials: chloroquine, pamaquine.

Antibiotics:  penicillin, streptomycin and chloramphenicol.