Functionalized Organic Compounds-II(Carbonyl compounds ,carboxylic acids and its derivatives)

Paper Code: 
CHY- 402
Credits: 
02
Contact Hours: 
30.00
Max. Marks: 
100.00
Objective: 

Course Objectives:

This course will enable the students to –

  1. make students learn how different compounds are prepared by the reactions of carbonyl moiety.
  2. introduce how the reactivity can be explained to allow the introduction of functional group next to carbonyl group.

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment Strategies

 

Paper Code

Paper Title

 

CHY 402

 

Functionalized Organic Compounds-II

(Carbonyl Compounds, Carboxylic Acids and its Derivatives)

(Theory)

 

The students will be able to –

CO65: predict the reactivity of different carbonyl compounds (saturated and unsaturated aldehydes and ketones) and their methods of formation

CO66: outline the nucleophilic addition reaction mechanism for carbonyl compounds

CO67: recognize the mechanism and products in some name reactions following nucleophilic addition mechanism.

CO68: describe the acidity and reactivity of active methylene groups

CO69: discuss the synthesis of carboxylic acids and its derivatives from different substrates

CO70: analyze the factors of the relative acidities of aliphatic and aromatic carboxylic acids by considering the inductive, resonance and steric effects on the neutral (conjugate acid) form and the anionic (conjugate base) form and compare with alcohols and phenols
  • Interactive Lectures
  • Group Discussions
  • Tutorials,
  • Quiz
  • Problem solving sessions

 

 

 

 

 

 
  • Multiple choice questions
  • Assertions and reasoning
  • Short answer questions
  • Long answer questions
  • Assignments
  • Quiz

 

 

 

7.00
Unit I: 
Chemistry of Aldehydes and Ketones

Synthesis from acid chlorides, 1,3-dithianes and enamines, nitriles and carboxylic acids;mechanism of nucleophilic addition reaction to carbonyl group with particular emphasis on Benzoin,Perkin, aldol, Knoevenagel condensations,Reformatsky  reaction and Dieckman condensation,condensation with ammonia & its derivatives including reactions with primary & secondary amines, Mannich & Wittig reactions.

7.00
Unit II: 
Oxidation & Reduction of Aldehydes & Ketones

Use of acetals as protecting groups.Oxidation of aldehydes, Baeyer-Villiger oxidation of ketones, Oppenaueroxidation. Cannizzaro’s reaction, MPV, Clemmensen, Wolff-Kishner, LiAlH4, NaBH4 reductions.

                                           

6.00
Unit III: 
Chemistry of Enolate ions, Enolsand α,β-Unsaturated Carbonyl Compounds

Introduction, acidity of α- hydrogens, keto-enoltautomerism of ethylacetoacetate, evidences in favour of keto-enoltautomerism,synthesis of ethylacetoacetate (Claisen condensation) and diethyl malonate, alkylation of ethylacetoacetate and diethyl malonate.

 

7.00
Unit IV: 
Chemistry of Carboxylic Acid

Pre requisite:Nomenclature, structure and physical properties, reduction of carboxylic acid  to primary alcohol.

Acidity of carboxylic acids, effect of substituents on acidity; methods of preparation, reactions of carboxylic group, conversion of carboxylic acid into acid chlorides, anhydrides, amides, & esters, decarboxylation, Hell VolhardZelinsky reaction.

5.00
Unit V: 
Carboxylic Acid Derivatives: Esters, Acid chlorides, Amides and Anhydrides

Pre requisite:  Nomenclature, preparation of carboxylic acid derivatives.

Basicity,relative stability of acyl derivative,physical properties , chemical reactions , mechanism of esterification & hydrolysis ( acid & base catalysed ) ,mechanism and reactivity in nucleophilic acyl substitution.

 

References: 
  • Organic Chemistry; Fourth Edition; G. Marc Loudon; Oxford University Press, New York, 2002.
  • Organic Chemistry; Sixth Edition; Robert Thornton Morrison & Robert Neilson Boyd; Prentice-Hall of India Pvt. Ltd , New Delhi, 2004.
Academic Year: 
2018-2019
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