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Bioinorganic Chemistry
Paper Code:
CHY - 424(B)
Credits:
3
Contact Hours:
45.00
Max. Marks:
100.00
Objective:
To learn the importance of metalloenzymes used in biosystems and metals in medicine.
8.00
Unit I:
Metal Ions in Living System
Pre requisite: Essential and trace elements, macrominerals - a general idea metal ions in biological systems: bulk and trace metals with special reference to Na, K, Mg, Fe, Cu
• Principles of coordination chemistry in biological systems, HSAB concept, chelate effect, irving Williams series, pKa values of coordination ligands, tuning of redox potential, biopolymer effects, ligand exchange rates, substitution raeactions, electrone transfer reactions.
• Molecular mechanism – ion transport across membranes, active transport of Na-K (ion pumps),
• Chlorophyll and their role in photosynthesis, (Calcium cycle and quantum efficiency) PS I and PS II system.
10.00
Unit II:
Iron and Calcium in Biological Systems
Metal Storage and Transport: Ferritin, Transferrin, Siderophores, Celluloplasmin,and serum albumin for copper.
Calcium in Biological Systems: calcium in living cells, transport and regulation of Ca2+ ions in higher organisms, molecular aspects of intramolecular processes, extracellular binding proteins.
12.00
Unit III:
Metalloenzymes
Zinc enzymes-carboxypeptidase and carbonic anhydrase; alcoholic dehydrogenase, iron enzymes – catalase, peroxidase and cytochrome P-450; copper enzymes – superoxide dismutase; vitamin B12 and B12 coenzymes.
7.00
Unit IV:
Metals in Medicine
Fe, Zn and Cu deficiency in toxicity- Cu overload and wilson’s disease, iron toxicity, toxicity of As, Cd, Hg and Pb, metal complexes in medicines, chelation therapy, BAL, penicilamine, poly amino carboxylic acid and desferrioxamine-gold compounds, rheumatoid arthritis – pt complexes as anticancer, metal complexes in radiodiagnosis, MRI.
8.00
Unit V:
Metal-nucleic Acid Interactions
Basics- nucleic acid structure, fundamental interactions and reactions with nucleic acids, applications of different metal complexes that binds nucleic acids, conformational probes, metal-nucleic acid interactions with special references to zinc finger protein.
Essential Readings:
- Principles of Bioinorganic Chemistry; First Edition; S. J. Lippard, J.M. Berg; Panima Publishing Corporation, New Delhi, 2005.
- Bioinorganic Chemistry; First Edition; I.Bertini, H.B.Gray, S.J.Lippard, J.S.Valentine; Viva Books Pvt Ltd., New Delhi, 1998.
- Bioinorganic Chemistry; First Edition; M.Satake, Y.Mido; Discovery Publishing House, New Delhi, 2003.
- Principles of Biochemistry, IIIrd Ed., A. L. Lehninger, McMillan Press, U.K. 2002
Academic Year:
