Biomolecules

Paper Code: 
CHY-512
Credits: 
3
Contact Hours: 
45.00
Objective: 

Course Objectives:

This course will enable the students to -

1. understand the basic processes which link the biological systems with the chemical systems.

2. have an insight about the three-dimensional (3D) structure of macromolecules

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

Paper Code

Paper Title

 

 

CHY-512

 

 

 

 

 

 

 

Biomolecules

 

 

 

 

 

The students will be able to –

 

CO132: discuss the structures, preparations and chemical reactivities of polynuclear hydrocarbons.

 CO133: identify the chemical elements and functions of carbohydrates and interconvert & differentiate between simple and complex structures of the same.

CO134: sketch a detailed account of nucleic acids and their components with special emphasis on polynucleotides like DNA and RNA.

CO135: summarize the functions of amino acids, peptides & proteins and identify the influence of the three dimensional shape and subunits of a protein on its function.

 CO136: discuss the composition and functioning of lipids with reference to their characteristic properties like iodine value, saponification, hydrogenation and reversion.

Interactive Lectures

 • Demonstrations

 • Discussions

• Tutorials

• Quiz

• Problem solving

 

 

• Quiz

• Closed book and open-book tests

 • Assignment

• Group Activity • Semester End Exam

 

 

 

10.00
Unit I: 
Polynuclear Hydrocarbons

Structure, preparation, important reactions and derivatives of naphthalene, anthracene and phenanthrene.

 

12.00
Unit II: 
Carbohydrates

Occurrence, classification and their biological importance

Monosaccharides: Constitution and absolute configuration of glucose and fructose, epimers and anomers, mutarotation, determination of ring size of glucose and fructose, Haworth projections and conformational structures; Interconversions of aldoses and ketoses; Killiani-Fischer synthesis and Ruff & Wohl degradation.

Disaccharides – Structure of maltose, lactose and sucrose,α& β glycosidic linkages, reducing & non-reducing sugars

Polysaccharides – Elementary treatment of starch, cellulose and glycogen.

8.00
Unit III: 
Nucleic Acids

Components of nucleic acids (DNA and RNA), nucleosides and nucleotides; double helical structure of DNA, Structure, synthesis and reactions of: Adenine, Guanine, Cytosine, Uracil and Thymine; Structure of polynucleotides.

8.00
Unit IV: 
Amino acids, Peptides and Proteins

Amino acids, Peptides and their classification : α-Amino Acids - Synthesis, ionic properties and reactions. Zwitterions, pKa values, isoelectric point and electrophoresis; Glycoproteins.

Study of peptides: Determination of their primary structures-end group analysis, methods of peptide synthesis. Synthesis of peptides using N-protecting, C-protecting and C-activating groups . Solid-phase synthesis, denaturation and renaturation.

7.00
Unit V: 
Lipids

Introduction to oils and fats; common fatty acids present in oils and fats, Hydrogenation of fats and oils, Saponification value, acid value, iodine number. Reversion and rancidity.

 

References: 
  • Organic Chemistry, Vol 2; Sixth Edition; I.L. Finar; Pearson Education, New Delhi, 2002.
  • Organic Chemistry; Seventh Edition; R. T. Morrison, R. N. Boyd, S.K. Bhattacharjee; Pearson Education India, New Delhi, 2010.
  • Lehninger Principles of Biochemistry; Seventh Edition; David L. Nelson, Michael M. Cox; W H Freeman,2017.

 

Academic Year: 
2021-2022
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