Laboratory course IX

Paper Code: 
CHY-515
Credits: 
2
Contact Hours: 
60.00
Objective: 

Course Objectives:

This course will enable the students to –

 

  1. provide knowledge of synthesis by conventional and non-conventional methods.
  2. be acquainted with the basic common laboratory techniques.

 

Course Outcomes (COs):

Course

Learning outcomes

(at course level)

Learning and teaching strategies

Assessment

Strategies

Paper Code

Paper Title

 

 

 

 

 

CHY-515

 

 

 

 

 

 

 

 

Lab Course IX

 

 

 

The students will be able to –

 

CO148: demonstrate and apply common laboratory techniques including refluxing, distillation, recrystallization, vacuum filtration, extraction, thin layer chromatography in the prescribed synthesis

CO149: synthesize various organic compounds through conventional methods as well as green methods
  • Class Lecture
  • Discussion
  • Demonstration
  • Substantial laboratory-based practical component and experiments

 
  • Continuous Assessment (practical test)
  • Viva Voce
  • Semester End Exams

 

 

 

Unit I: 

Organic Chemistry                                                                                  60 hrs

Basic techniques involved in synthetic organic chemistry

  1. Different types of glass wares
  2. Filtration
  3. Distillation (distillation at atmospheric pressure, steam distillation, fractional distillation and distillation at reduced pressure).
  4. Recrystallization and melting point correction.
  5. Use of decolourising carbon.
  6. Thin layer chromatography.

Synthesis (Green /Conventional))

  1. One step synthesis
  1. Aldol condensation :  Synthesis of dibenzal propanone  
  2. Acetylation  :  Synthesis of acetanilide from aniline
  3. Pechmann Condensation for Coumarin synthesis  : Clay catalysed solid state synthesis of 7-hydroxy -4-methyl coumarin
  4. Diazotisation : Preparation of Methyl orange/Methyl red
  5. Aromatic Electrophilic Substitution : Bromination of Phenol
  6. Rearrangement : Preparation of Phenytoin from Benzil and Urea

b. Two step synthesis

i. Benzoin → benzil → benzilic acid (calculation of atom economy required).

ii. Benzophenone → benzopinacol → benzapinacolone

iii. Acetanilide → p-bromoacetanilide → p-bromoaniline

iv. Acetanilide→ p-nitro acetanilide→ p-nitro aniline

v. Pthalic anhydride → Pthalimide → Anthranilic Acid

 

References: 
  • Vogel’s Textbook of Practical Organic Chemistry; Fifth Edition; B.S. Furniss, A.J. Hannaford, P.W.D. Smith, A.R. Tatchell; Pearson Education, New Delhi, 2003.
  • Monograph on Green Chemistry- Laboratory Experiments- Laboratory Task Force Committee , DST
  • University Practical Chemistry; Second Edition; P.C.Kamboj, Vishal Publishing House,New Delhi; 2019.

 

Academic Year: 
2021-2022
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