SELECTED TOPICS IN ORGANIC CHEMISTRY

Paper Code: 
CHY 401
Credits: 
3
Contact Hours: 
45.00
Max. Marks: 
100.00
Objective: 

Course Objectives:

This course will enable the students to –

  • develop a perspective towards different useful avenues of organic chemistry and their utility in interdisciplinary sciences.

 

Course Outcomes (COs):

Course Outcomes

Teaching learning strategies

Assessment

Strategies

  
 

On completion of this course, the students will be able to-

 

CO48: discuss the structures, preparations and chemical reactivity of polynuclear hydrocarbons and their important derivatives.

CO49: outline mechanisms for reactions involving heterocycles (five and six membered) as starting materials and propose syntheses of heterocycles from the major classes.

CO50: describe some of the important methods of preparation and properties of aliphatic and aromatic nitro and amino compounds mechanistically.

CO51: summarize the functions of amino acids, peptides & proteins and sketch a detailed account of nucleic acids and their components with special emphasis on polynucleotides like DNA and RNA.

CO52: describe the structure and functions of carbohydrates & differentiate between simple and complex structures of the same.
  • Class lectures
  • Tutorials
  • Group discussions
  • Use of models
  • Assertion and reasoning
  • Technology enabled learning
  • Peer learning

 
  • Oral and written examinations
  • Problem solving exercises
  • Assignments
  • Quiz
  • Efficient delivery using seminar presentations
  • Group activity
  • Multiple choice questions
  • Short answer type questions
  • Assertion and reasoning

 

  

 

9.00
Unit I: 
Polynuclear hydrocarbons

Structure, preparation and important reactions of naphthalene, anthracene and phenanthrene.

9.00
Unit II: 
Heterocyclic Compounds

Classification and nomenclature, structure, aromaticity in 5-numbered and 6-membered rings containing one heteroatom, synthesis, reactions and mechanism of substitution reactions of furan, pyrrole, thiophene and pyridine, comparison of basicity.

 

9.00
Unit III: 
Nitrogen Containing Functional Groups

Nitro compounds- preparation and important reactions.

Amines- effect of substituent and solvent on basicity, preparation and properties, Gabriel phthalimide synthesis, carbylamine reaction, Mannich reaction, Hoffmann’s exhaustive methylation, Hofmann-elimination reaction, distinction between 1°, 2° and 3° amines with Hinsberg reagent and nitrous acid.Diazonium salts-preparation and synthetic applications.

 

9.00
Unit IV: 
Amino Acids, Proteins and Nucleic acids

Amino acids - classification, structure and stereochemistry, acid base behaviour, isoelectric point, electrophoresis, preparation and reactions of α-amino acids.
Proteins- peptide linkages, structure and classification of primary, secondary and tertiary proteins and denaturation.
Nucleic acids- introduction, protein synthesis, functions.
Self-Study: Structure of nucleic acids, ribonucleosides and ribonucleotides, double helical structure of DNA.

 

9.00
Unit V: 
Carbohydrates

Classification and nomenclature, monosaccharides, mechanism of osazone formation, interconversion of glucose and fructose, stereochemistry of glucose, chain lengthening and chain shortening of aldoses, configuration of monosaccharides, erythro and threo diastereomers, conversion of glucose into mannose. formation of glycosides, ethers and esters, determination of ring size of monosaccharides.
Cyclic structure of D-(+)-glucose - mechanism of mutarotation

 

Essential Readings: 
  • Organic Chemistry, Sixth Edition; R. T. Morrison, R. N. Boyd; Pearson Education India, New Delhi, 2017.
  • Heterocyclic Chemistry, Vol. II, First Edition; R.R. Gupta and M. Kumar; Springer (India) Pvt. Ltd., 2005.

 

References: 

SUGGESTED READING:

  • Organic Chemistry, Second Edition; Jonathan Clayden, Nick Greeves and Stuart Warren; Oxford University Press, USA, 2014.
  • Organic Chemistry, Vol. I , Sixth Edition; I.L. Finar; Pearson Education, New Delhi2002.
  • Organic Chemistry, Sixth Edition; G. Marc Loudon, J. Parise; WH Freeman, New York, 2015.

 

e-RESOURCES:

 

Academic Year: 
2022-2023
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