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Guest lecture by Dr. P. V. Bhartam on anticancer agents and drug design
Report
Date: 09/10/2017
Venue: A.V hall
Speaker: Dr. P.V. Bharatam, Department of Medicinal Chemistry, NIPER, S.A.S. Nagar (Mohali), Punjab
Prof. P.V. Bhartam delivered a lecture on anticancer agents and design. The lecture was attended by PG Chemistry students and Research Scholars. His lecture focused on Pharmacoinformatics studies on Human Topoisomerase- II, exploring the mechanism of enzyme inhibition. Pharmacoinformatics come from Greek word ‘pharmacon’ (Biologically active substances) and information technology. he said that this discipline evolved from communication between medicine/pharmacy and computer science. The study is concerned with modelling and simulation of drugs behaviour and the technique employed includes molecular docking, molecular dynamics, virtual screening etc. The students got acquainted with the catalytic cycle of Topoisomerase- II, an enzyme which is abundantly present in cancerous cells. This enzyme modulates the topological state of DNA in the cell and regulates DNA over winding and under winding and remove knots.