Introduction to Biomolecules

Paper Code: 
CHY 125 B
Contact Hours: 
30.00
Objective: 

To learn the basic processes which link the biological systems with the chemical systems.

7.00
Unit I: 
The Matrix of Life

Origin of Life: elementary idea of prokaryotic and eukaryotic cell, difference between plant and animal cell, cell organelles and their functions: plasma membrane, chloroplast,   mitochondria, golgi bodies, endoplasmic reticulum, lysosomes, ribosomes, nucleus.

Chemical bonds: Hydrogen bonds, covalent, ionic, van der Waals interactions.

6.00
Unit II: 
Unit-II: Proteins

Amino acids: Essential and non essential, structure of zwitterions, Synthesis of amino acids by reductive amination , GS-GOGAT system and transamination,

Structure of proteins: primary, secondary-α helix and β pleated sheets, tertiary and Quaternary structure.

   

7.00
Unit III: 
Carbohydrates

Classification, structure and functions of monosaccharides, disaccharides, polysaccharides: starch, cellulose, glycogen, chitin and pectins.

Glycoconjugates: Proteoglycans, glycoproteins and glycolipids.

                                                 

 

5.00
Unit IV: 
Lipids

Structure and functions of lipids, saturated and unsaturated fatty acids, classification: simple, compound and derived lipids (steroids and cholesterol). Synthesis of long chain fatty acids, α-oxidation, β-oxidation.

5.00
Unit V: 
Nucleic Acids

DNA: Double helical structure of DNA, types of DNA -A, B, C and Z forms, replication.                                                                                                              

RNA: RNA structure and its types- r RNA, m RNA, and t RNA, ribozymes.

                            

Essential Readings: 
  1. Principles of Biochemistry; Third Edition; A.L. Lehninger;  McMillan Press Limited, London, 2002.
  2. Biochemistry; Fifth Edition; L. Stryer; W.H. Freeman and Company, 2002.
  3. Biochemistry; First Indian Reprint; J. D. Rawn; Tanima Publishing Corporation, New Delhi, 2004.
  4. Biochemistry; Second Edition; Voet and Voet;  John Wiley and Sons Inc., New York, 1995.
  5. Outline of Biochemistry; Fourth Edition; E.E. Conn and P.K. Stumpf; John Wiley and Sons Inc., New Delhi, 1994.
Academic Year: